{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T21:20:58Z","timestamp":1790025658225,"version":"4.0.1"},"reference-count":82,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T00:00:00Z","timestamp":1737331200000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82405173"],"award-info":[{"award-number":["82405173"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["iubmb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioFactors"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Curcumin, a compound from\n                    <jats:italic>Curcuma longa<\/jats:italic>\n                    L., has significant anti\u2010inflammatory properties. However, the mechanisms underlying its anti\u2010inflammatory activity in dextran sodium sulfate (DSS)\u2010induced ulcerative colitis (UC) remain inadequately understood. This study aimed to further elucidate the molecular mechanisms of curcumin DSS\u2010induced UC mice. Our data showed that curcumin alleviated DSS\u2010induced colitis by reducing intestinal damage and inflammation, increasing goblet cells in colon tissues. Enzyme\u2010linked immunosorbent assay revealed that curcumin reduced the expression of inflammatory cytokines (tumor necrosis factor\u2010alpha, interleukin\u20101\u03b2, and interleukin\u20108) in serum and myeloperoxidase in colon tissues. A comprehensive analysis integrating network pharmacology and RNA sequencing (RNA\u2010seq) revealed significant enrichment of the nuclear factor kappa B (NF\u2010\u03baB) signaling pathways. Notably, RNA\u2010seq analysis demonstrated that curcumin significantly downregulated the mRNA expression of sphingosine kinase 1 (SphK1). Furthermore, molecular docking analysis showed that curcumin can bind to SphK1 and NF\u2010\u03baB. Additionally, curcumin was found to inhibit the activation of the SphK1\/NF\u2010\u03baB signaling pathway in DSS\u2010induced UC colon tissue. This study addresses pharmacologic and mechanistic perspectives of curcumin that ameliorates DSS\u2010induced UC and inflammatory response.\n                  <\/jats:p>","DOI":"10.1002\/biof.70001","type":"journal-article","created":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T19:15:31Z","timestamp":1737400531000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Curcumin attenuates ulcerative colitis via regulation of\n                    <scp>Sphingosine kinases 1<\/scp>\n                    \/\n                    <scp>NF<\/scp>\n                    \u2010\n                    <scp>\u03baB<\/scp>\n                    signaling pathway"],"prefix":"10.1002","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-4929-4417","authenticated-orcid":false,"given":"Xiuli","family":"Zhang","sequence":"first","affiliation":[{"name":"College of Integrative Medicine Fujian University of Traditional Chinese Medicine  Fuzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Integrative Medicine Fujian University of Traditional Chinese Medicine  Fuzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingting","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Integrative Medicine Fujian University of Traditional Chinese Medicine  Fuzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangyi","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Integrative Medicine Fujian University of Traditional Chinese Medicine  Fuzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiumao","family":"Lin","sequence":"additional","affiliation":[{"name":"College of Integrative Medicine Fujian University of Traditional Chinese Medicine  Fuzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingshui","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Integrative Medicine Fujian University of Traditional Chinese Medicine  Fuzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Wu","sequence":"additional","affiliation":[{"name":"Basic Medical Experimental Teaching Center, School of Basic Medical Sciences Fujian Medical University  Fuzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The First Affiliated Hospital of Fujian Medical University  Fuzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0493-0155","authenticated-orcid":false,"given":"Yao","family":"Lin","sequence":"additional","affiliation":[{"name":"College of Integrative Medicine Fujian University of Traditional Chinese Medicine  Fuzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60751-X"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60750-8"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2014.07.002"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32448-0"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-020-00360-x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-018-1449-z"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(21)00223-5"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0228615"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06568-5"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00072"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1228704"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2655"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2019.04.052"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2020.153438"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2010.08.014"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods6100092"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.6b00975"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.14911"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/biof.1716"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2022.115041"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2015.02.019"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2013.08.006"},{"key":"e_1_2_10_24_1","first-page":"3053","article-title":"Curcumin and resveratrol suppress dextran sulfate sodium\u2010induced colitis in mice","volume":"19","author":"Zhang L","year":"2019","journal-title":"Mol Med Rep"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0705241"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00275.2011"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2019.112230"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15054"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i48.9256"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2006.08.008"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2016.06.018"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2021.11.004"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41436-019-0672-1"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41576-021-00326-y"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12008"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.743454"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1080\/13880209.2024.2378012"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.665376"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2022.108620"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/pbi.14354"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.8b00312"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2009.2538"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2023.13139"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.01.002"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.05.008"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X22500756"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcme.2016.05.005"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e318276977d"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00449.2002"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-009-0843-z"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.7656"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v29.i36.5226"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202301391"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.4103\/1319-3767.173759"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/718617"},{"key":"e_1_2_10_56_1","first-page":"1341","article-title":"Animal models of ulcerative colitis and their application in drug research","volume":"7","author":"Low D","year":"2013","journal-title":"Drug des Devel Ther"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2017.044"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X22500100"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-022-01780-4"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60150-0"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S363840"},{"issue":"8","key":"e_1_2_10_62_1","first-page":"56","article-title":"The role of proinflammatory and immunoregulatory cytokines in the pathogenesis of ulcerative colitis","volume":"30","author":"Murata Y","year":"1995","journal-title":"J Gastroenterol"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2021.103017"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v29.i18.2733"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01540912"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-003-1219-z"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.03.022"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.02.016"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf501487v"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2016.07.003"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2017.03.003"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2018.02.012"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.06.071"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2013.08.040"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19020420"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu9030288"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2016.35"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.08-118109"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13577-019-00283-z"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2018.05.015"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S278267"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2022.09.012"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2022.2101530"}],"container-title":["BioFactors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iubmb.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/biof.70001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T05:39:02Z","timestamp":1765517942000},"score":1,"resource":{"primary":{"URL":"https:\/\/iubmb.onlinelibrary.wiley.com\/doi\/10.1002\/biof.70001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":82,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1002\/biof.70001"],"URL":"https:\/\/doi.org\/10.1002\/biof.70001","archive":["Portico"],"relation":{},"ISSN":["0951-6433","1872-8081"],"issn-type":[{"value":"0951-6433","type":"print"},{"value":"1872-8081","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-08-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70001"}}