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Cepharanthine (CEP), an alkaloid with a bisbenzyl\u2010isoquinoline skeleton, was isolated from the\n                    <jats:italic>Stephania<\/jats:italic>\n                    genus. The research articles on this alkaloid invariably cite its usefulness due to its biological activity. The relevant keywords were searched in various databases, and two independent reviewers carefully removed the duplicates. The alkaloid exhibits multiple biological activities, such as anti\u2010inflammatory, antioxidant, and anti\u2010viral, apart from anti\u2010cancer activities. It has been used to treat diverse medical conditions, including venomous snakebites. One of the key reactions of this alkaloid involves its ability to reverse multidrug resistance.\n                  <\/jats:p>","DOI":"10.1002\/biof.70064","type":"journal-article","created":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T02:38:55Z","timestamp":1764383935000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cepharanthine as a Biofactor: Molecular Functions, Signaling Pathway Modulation and Therapeutic Relevance in Cancer and Drug Resistance"],"prefix":"10.1002","volume":"51","author":[{"given":"Hector Hern\u00e1ndez","family":"Parra","sequence":"first","affiliation":[{"name":"Departamento de Farmacia Facultad de Qu\u00edmica, Universidad Nacional Aut\u00f3noma de M\u00e9xico  Mexico City Mexico"},{"name":"Departamento de Farmacolog\u00eda Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional (CINVESTAV\u2010IPN)  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9ctor Adri\u00e1n","family":"Garc\u00eda\u2010Gasca","sequence":"additional","affiliation":[{"name":"Departamento de Farmacia Facultad de Qu\u00edmica, Universidad Nacional Aut\u00f3noma de M\u00e9xico  Mexico City Mexico"},{"name":"Departamento de Farmacolog\u00eda Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional (CINVESTAV\u2010IPN)  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila Ira\u00eds","family":"Pe\u00f1a\u2010Corona","sequence":"additional","affiliation":[{"name":"Departamento de Farmacia Facultad de Qu\u00edmica, Universidad Nacional Aut\u00f3noma de M\u00e9xico  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7940-1100","authenticated-orcid":false,"given":"Gerardo","family":"Leyva\u2010G\u00f3mez","sequence":"additional","affiliation":[{"name":"Departamento de Farmacia Facultad de Qu\u00edmica, Universidad Nacional Aut\u00f3noma de M\u00e9xico  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harshada Manish","family":"Adhyapak","sequence":"additional","affiliation":[{"name":"Department of Chemistry Manipal Institute of Technology, Manipal Academy of Higher Education  Manipal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nidhishree Adruguli","family":"Sudhakara","sequence":"additional","affiliation":[{"name":"Department of Chemistry Manipal Institute of Technology, Manipal Academy of Higher Education  Manipal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8016-8991","authenticated-orcid":false,"given":"Nanjangud Venkatesh Anil","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Chemistry Manipal Institute of Technology, Manipal Academy of Higher Education  Manipal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1523-9116","authenticated-orcid":false,"given":"Daniela","family":"Calina","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy University of Medicine and Pharmacy of Craiova  Craiova Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7301-8151","authenticated-orcid":false,"given":"Javad","family":"Sharifi\u2010Rad","sequence":"additional","affiliation":[{"name":"Universidad Esp\u00edritu Santo  Samborond\u00f3n Ecuador"},{"name":"Department of Medicine College of Medicine, Korea University  Seoul Republic of Korea"},{"name":"Centro de Estudios Tecnol\u00f3gicos y Universitarios del Golfo  Veracruz Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,28]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-024-03396-x"},{"key":"e_1_2_15_3_1","article-title":"Anticancer Drug Discovery Based on Natural Products: From Computational Approaches to Clinical Studies","volume":"12","author":"Chunarkar\u2010Patil P.","year":"2024","journal-title":"Biomedicine"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2019.152956"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28135019"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2006.12.001"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115107"},{"key":"e_1_2_15_8_1","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1248\/yakushi1947.86.10_984","article-title":"Cepharanthine and Related Compounds. 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A Synthesis of 1\u2010(3\u2010Bromo\u20104\u2010Methoxybenzyl)\u20101,2,3,4\u2010Tetrahydro\u20106\u2010Methoxy\u20102\u2010Methyl\u20107\u2010Isoquinolinol (Studies on the Syntheses of Heterocyclic Compounds. 183)","volume":"87","author":"Kametani T.","year":"1967","journal-title":"Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(00)90667-1"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(01)89985-8"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.16.217"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2019.01.028"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb1953.3.250"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1536375"},{"key":"e_1_2_15_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-023-02537-y"},{"key":"e_1_2_15_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/095632020101200506"},{"key":"e_1_2_15_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-9598(08)60206-0"},{"key":"e_1_2_15_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.14533"},{"key":"e_1_2_15_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/np400084t"},{"key":"e_1_2_15_21_1","first-page":"1396","article-title":"Phytochemical Screening and Antibacterial Activities of Tuber Extract of Stephania pierrei Diels","volume":"45","author":"Kamonwannasit S.","year":"2018","journal-title":"Chiang Mai Journal of Science"},{"key":"e_1_2_15_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2012.10.052"},{"key":"e_1_2_15_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9422(85)80072-8"},{"key":"e_1_2_15_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/np50045a006"},{"key":"e_1_2_15_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13002-015-0019-1"},{"key":"e_1_2_15_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seppur.2013.12.016"},{"key":"e_1_2_15_27_1","first-page":"1515","article-title":"Intratumoral Administration of Biological Preparations\u2014Recommendation for Integrative Medicine","volume":"28","author":"Ebina T.","year":"2001","journal-title":"Gan To Kagaku Ryoho. 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