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The use of natural products, such as\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Crocus sativus<\/jats:italic>\n                    <\/jats:styled-content>\n                    tepals extract (CTE) could be a promising approach to alleviate metabolic disorders. The aim was to investigate the potential ameliorative mechanisms of CTE in metabolic disorders induced by a high\u2010fat diet in an animal model, focusing on the composition of the gut microbiota and its relationship with the gut\u2010liver axis. We analyzed liver\u2010related biochemical and morphological parameters in mice fed a 60% fat diet for 14\u2009weeks and orally treated with CTE during the last 5\u2009weeks of the diet. In addition, jejunal and liver histology, intestinal barrier integrity, inflammation and oxidative stress, liver inflammation and lipid metabolism were investigated. The results showed that oral administration of CTE restored the composition of the gut microbiota and specifically promoted short\u2010chain fatty acids\u2010producing and anti\u2010inflammatory bacterial genera. It also improved intestinal barrier integrity and reduced inflammation in the jejunum and liver, along with a suppression of\n                    <jats:italic>Fas<\/jats:italic>\n                    and\n                    <jats:italic>CerS6<\/jats:italic>\n                    expression in the liver and a reduction in circulating free fatty acids and \u03b2\u2010hydroxybutyrate levels. Our results indicate a possible link between the gut microbiota and the metabolic benefits of treatment with CTE, suggesting its therapeutic potential for the prevention or treatment of metabolic disorders.\n                  <\/jats:p>","DOI":"10.1002\/biof.70083","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T07:45:33Z","timestamp":1770882333000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Oral Administration of\n                    <i>Crocus sativus<\/i>\n                    Tepals Extract Restores High\u2010Fat Diet\u2010Induced Gut Dysbiosis and Modulates Intestinal Inflammation and Hepatic Lipid Metabolism"],"prefix":"10.1002","volume":"52","author":[{"given":"Biljana","family":"Bursa\u0107","sequence":"first","affiliation":[{"name":"Department of Biochemistry Institute for Biological Research \u201cSini\u0161a Stankovi\u0107\u201d\u2010National Institute of the 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