{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T19:18:09Z","timestamp":1789067889704,"version":"build-2803163510"},"reference-count":58,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["RTG 2155 \u201cProMoAge\u201d"],"award-info":[{"award-number":["RTG 2155 \u201cProMoAge\u201d"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["iubmb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioFactors"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Human selenium\u2010binding protein 1 (SELENBP1) catalyzes the oxidation of the gaseous methionine degradation product, methanethiol. We previously identified a\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Caenorhabditis elegans<\/jats:italic>\n                    <\/jats:styled-content>\n                    ortholog, SEMO\u20101, that has the same methanethiol oxidase (MTO) activity. Here, we report the identification and functional characterization of another\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>C. elegans<\/jats:italic>\n                    <\/jats:styled-content>\n                    ortholog of human SELENBP1, SEMI\u20101. In contrast to SELENBP1 and SEMO\u20101, SEMI\u20101 (SELENBP1\u2010homolog, MTO inactive) lacks MTO activity. Notably,\n                    <jats:italic>semi\u20101<\/jats:italic>\n                    expression is confined to thermosensory AFD (amphid finger\u2010like endings D) and oxygen\u2010sensing BAG (bag\u2010like dendritic ending) neurons, as demonstrated using a SEMI\u20101::GFP reporter. Depletion of SEMI\u20101 results in increased lifespan, improved physiological parameters (motility, progeny), and reduced accumulation of age pigments during aging. SEMI\u20101\u2010deficient nematodes are more resistant to the redox cycler paraquat than wild\u2010type worms. On the other hand, they show enhanced susceptibility to selenite exposure, indicating a role for SEMI\u20101 in conferring selective stress resistance. We also show that SEMI\u20101 deficiency is associated with impaired thermotaxis in\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">C. elegans<\/jats:styled-content>\n                      ,\n                    <\/jats:italic>\n                    which is consistent with the role of AFD neurons in thermosensation. In conclusion, SEMI\u20101 is a neuronal SELENBP1 ortholog in\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>C. elegans<\/jats:italic>\n                    <\/jats:styled-content>\n                    that lacks MTO activity and impairs oxidative stress resistance and shortens lifespan. As a trade\u2010off, it contributes to\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>C. elegans<\/jats:italic>\n                    <\/jats:styled-content>\n                    selenite resistance and thermotaxis. The observed phenotypes of SEMI\u20101 deficiency suggest the existence of MTO\u2010independent effects of other SELENBP1 homologs.\n                  <\/jats:p>","DOI":"10.1002\/biof.70118","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T03:10:38Z","timestamp":1779765038000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<scp>SEMI<\/scp>\n                    \u20101, A Novel Neuronal Selenium\u2010Binding Protein 1 Homolog Without Methanethiol Oxidase Activity, Modulates Stress Resistance, Lifespan, and Thermotaxis in\n                    <scp>\n                      <i>C. elegans<\/i>\n                    <\/scp>"],"prefix":"10.1002","volume":"52","author":[{"given":"Weiye","family":"Gong","sequence":"first","affiliation":[{"name":"Institute of Nutritional Sciences, Nutrigenomics Section Friedrich\u2010Schiller\u2010Universit\u00e4t Jena  Jena 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Friedrich\u2010Schiller\u2010Universit\u00e4t Jena  Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verena Alexia","family":"Ohse","sequence":"additional","affiliation":[{"name":"Institute of Nutritional Sciences, Nutrigenomics Section Friedrich\u2010Schiller\u2010Universit\u00e4t Jena  Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9403-6431","authenticated-orcid":false,"given":"David","family":"Guerrero\u2010G\u00f3mez","sequence":"additional","affiliation":[{"name":"Instituto de Biomedicina de Sevilla Hospital Universitario Virgen del Roc\u00edo\/CSIC\/Universidad de Sevilla  Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscila Yumi Tanaka","family":"Shibao","sequence":"additional","affiliation":[{"name":"Leibniz Institute on Aging \u2013 Fritz\u2010Lipmann\u2010Institute (FLI)  Jena 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