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This study aimed to investigate whether MSC\u2010exos attenuate HS by modulating SCs and to elucidate the underlying mechanisms. HS and normal skin tissues were obtained from patients. MSCs, SCs, and fibroblasts were isolated from BALB\/c mice. SCs and HS mouse models were treated with MSC\u2010exos. SCs under various treatments were co\u2010cultured with fibroblasts. mRNA and protein levels were assessed by qRT\u2010PCR, western blot, immunofluorescence, and immunohistochemical staining. Cell migration, proliferation, and apoptosis were evaluated by wound healing assay, CCK\u20108 assay, and TUNEL assay, respectively. HS tissue morphology was examined by Hematoxylin\u2013eosin and Masson staining. The targeting of miR\u201029a\u20103p towards PDGFRB was validated using a dual\u2010luciferase reporter assay. In patient HS tissues, downregulated miR\u201029a\u20103p was negatively correlated with upregulated PDGFRB. MSC\u2010exo\u2010delivered miR\u201029a\u20103p suppressed SCs proliferation and migration, promoted SCs apoptosis, and reduced SCs\u2010secreted NGF, thereby inhibiting fibroblast migration and myofibroblast transformation. These effects were reversed by miR\u201029a\u20103p knockdown in MSCs. Furthermore, miR\u201029a\u20103p targeted and inhibited PDGFRB expression in SCs. Silencing PDGFRB abolished the promoting effects of miR\u201029a\u20103p inhibition on SCs, which was rescued by the PAK1 activator FTY720. MSC\u2010exo\u2010delivered miR\u201029a\u20103p ameliorates HS by inhibiting SCs proliferation, migration and NGF secretion via the PDGFRB\/PAK1 axis to suppress myofibroblast transformation. Beyond the traditional focus on fibroblasts, this reveals an exosome\u2010SCs\u2010fibroblast network, providing a novel theoretical basis for HS treatment.<\/jats:p>","DOI":"10.1002\/biof.70120","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T03:54:48Z","timestamp":1780372488000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mesenchymal Stem Cell\u2010Derived Exosomal\n                    <scp>miR<\/scp>\n                    \u201029a\u20103p Improves Hypertrophic Scar by Inhibiting the Proliferation and Migration of Schwann Cells via the\n                    <scp>PDGFRB<\/scp>\n                    \/\n                    <scp>PAK1<\/scp>\n                    Axis"],"prefix":"10.1002","volume":"52","author":[{"given":"Chengyu","family":"Zang","sequence":"first","affiliation":[{"name":"Department of Burn and Plastic Surgery, Shandong Provincial Hospital Shandong University  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