{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T13:51:43Z","timestamp":1782481903022,"version":"3.54.5"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:00:00Z","timestamp":1782259200000},"content-version":"vor","delay-in-days":54,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["iubmb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioFactors"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Acute myeloid leukemia (AML) remains challenging to treat due to clinical heterogeneity and a lack of prognostic biomarkers. To address this, we developed a prognostic signature based on platelet\u2010related genes (PRGs). By analyzing transcriptomic data from TCGA\u2010LAML, GSE146173, and Beat AML 2.0 cohorts, we identified and validated an 11\u2010gene signature (PSME2, PPIF, SYTL4, S100A4, CCND3, SMIM15, PARVB, STXBP5, KCNMB1, GABRE, SLC50A1) using LASSO\u2010Cox regression. This model effectively stratified patients into high\u2010 and low\u2010risk groups with distinct survival outcomes (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) and demonstrated high predictive accuracy (1\u2010\/3\u2010\/5\u2010year AUC: 0.832\/0.782\/0.880). High\u2010risk patients exhibited immunosuppressive features, including upregulated immune checkpoints (CD274, CTLA4, HAVCR2, LAG3, PDCD1LG2, PDCD1), prominent monocyte infiltration, and reduced dendritic`11 cell activity. Drug sensitivity analysis suggested gefitinib, zebularine, and simvastatin as potential therapies for high\u2010risk AML (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). We further validated the signature's prognostic value using qPCR and clinical grouping. Notably, in\u00a0vitro studies indicated that KCNMB1 facilitates AML progression. In conclusion, our robust PRG\u2010based model elucidates the link between platelet biology, immune dysregulation, and therapeutic vulnerability in AML, offering clinical utility for risk stratification and treatment decisions.\n                  <\/jats:p>","DOI":"10.1002\/biof.70123","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T09:45:14Z","timestamp":1782294314000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Platelet\u2010Related Gene Signature Predicts Prognosis, Immune Landscape, and Drug Sensitivity in Acute Myeloid Leukemia"],"prefix":"10.1002","volume":"52","author":[{"given":"Yi","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Hematology The Second Affiliated Hospital of Anhui Medical University  Hefei Anhui China"},{"name":"Center of Hematology Research, Anhui Medical University  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanjia","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Hematology The Second Affiliated Hospital of Anhui Medical University  Hefei Anhui China"},{"name":"Center of Hematology Research, Anhui Medical University  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siqi","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Hematology The Second Affiliated Hospital of Anhui Medical University  Hefei Anhui China"},{"name":"Center of Hematology Research, Anhui Medical University  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajia","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology Tongling People's Hospital  Tongling Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhimin","family":"Zhai","sequence":"additional","affiliation":[{"name":"Department of Hematology The Second Affiliated Hospital of Anhui Medical University  Hefei Anhui China"},{"name":"Center of Hematology Research, Anhui Medical University  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,24]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-021-00509-w"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16360"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)00108-3"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-023-01424-6"},{"key":"e_1_2_12_6_1","first-page":"n2026","article-title":"Advances in Acute Myeloid Leukemia","volume":"375","author":"Newell L. 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