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In addition to the antimicrobial activity, some polyphenols modulate the immune response in a way that could enhance the clearance of invading pathogens. This study investigated four resveratrol\u2010derived dimeric compounds, dehydro\u2010\u03b4\u2010viniferin, (\u00b1)\u2010\n                    <jats:italic>trans<\/jats:italic>\n                    \u2010\u03b4\u2010viniferin, viniferifuran, and (\u00b1)\u2010\u03b5\u2010viniferin, for their antimicrobial activity against methicillin\u2010resistant\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">S. aureus<\/jats:styled-content>\n                      .\n                    <\/jats:italic>\n                    In addition, their immunomodulating properties in bacterially challenged dendritic cells were assessed. We identified dehydro\u2010\u03b4\u2010viniferin as exhibiting the most potent antimicrobial activity against methicillin\u2010resistant\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    <\/jats:styled-content>\n                    with a minimal inhibitory concentration of 2\u2009\u03bcg\/mL and a minimal bactericidal concentration of 8\u2009\u03bcg\/mL, respectively. Furthermore, dehydro\u2010\u03b4\u2010viniferin showed significant enhancement of the\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>S. aureus<\/jats:italic>\n                    <\/jats:styled-content>\n                    \u2010induced IL\u201012 production from bone marrow\u2010derived dendritic cells, which could be ascribed to a decrease in the production of IL\u201010. Only if dehydro\u2010\u03b4\u2010viniferin was administered to dendritic cells prior to bacterial stimulation, IL\u201012 production was increased; if added later, the increase in IL\u201012 was lost although the IL\u201010 production was reduced. This suggests that dehydro\u2010\u03b4\u2010viniferin interferes with the signaling pathway leading to IL\u201010, which in turn influences the IL\u201012 production in a time dependent manner. Collectively, dehydro\u2010\u03b4\u2010viniferin is a potent antimicrobial against methicillin\u2010resistant\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>S. aureus<\/jats:italic>\n                    <\/jats:styled-content>\n                    with enhancing effects on the bacterially induced IL\u201012 response in antigen\u2010presenting cells. We therefore suggest dehydro\u2010\u03b4\u2010viniferin as a promising antibiotic candidate against multidrug\u2010resistant Gram\u2010positive bacteria.\n                  <\/jats:p>","DOI":"10.1002\/biof.70128","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T03:18:09Z","timestamp":1782098289000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Resveratrol\u2010Derived Dimers With Antimicrobial and Immune\u2010Enhancing Activities"],"prefix":"10.1002","volume":"52","author":[{"given":"Peter Riber","family":"Johnsen","sequence":"first","affiliation":[{"name":"Department of Veterinary and Animal Sciences University of Copenhagen  Frederiksberg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Pinna","sequence":"additional","affiliation":[{"name":"Department of Food, Environmental and Nutritional Sciences (DeFENS) University of Milan  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