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Plant\u2010derived extracellular vesicles (PDEVs) have emerged as promising bioactive nanocarriers, but their roles in mitochondrial regulation and skin barrier homeostasis remain unclear. This study aimed to investigate the protective effects of extracellular vesicles derived from\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Alpinia zerumbet<\/jats:italic>\n                    <\/jats:styled-content>\n                    leaves (AZEVs) against UVB\u2010induced photoaging in HaCaT keratinocytes. The results indicated that AZEVs exhibited typical extracellular vesicle characteristics, with an average size of 150\u2009nm and a negative surface charge. Functionally, AZEVs significantly enhanced cell viability in UVB\u2010exposed HaCaT cells, reduced ROS accumulation, and restored mitochondrial membrane potential and ATP production. Moreover, AZEVs upregulated mitochondrial biogenesis\u2010related signaling pathway proteins (SIRT1, PGC\u20101\n                    <jats:italic>\u03b1<\/jats:italic>\n                    , Nrf2, and\n                    <jats:italic>p<\/jats:italic>\n                    \u2010AMPK\/AMPK) and TJ protein expression (ZO\u20101, occludin, and claudin\u20103), preserving barrier integrity and promoting wound healing. In addition, AZEVs are enriched in conserved miRNAs (miR166, miR159, and miR156) and a novel miRNA (novel_1), with predicted targets involved in redox regulation and energy metabolism. In summary, AZEVs protect keratinocytes against UVB\u2010induced damage by enhancing mitochondrial function, reducing oxidative stress, and preserving skin barrier integrity. These findings highlight AZEVs as a promising natural nanoplatform for anti\u2010photoaging and skin repair applications.\n                  <\/jats:p>","DOI":"10.1002\/biof.70134","type":"journal-article","created":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T03:44:12Z","timestamp":1783136652000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>Alpinia zerumbet<\/i>\n                    \u2010Derived Extracellular Vesicles Protect Against\n                    <scp>UVB<\/scp>\n                    \u2010Induced Photoaging by Enhancing Mitochondrial Bioenergetics and Skin Barrier Function"],"prefix":"10.1002","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6332-0613","authenticated-orcid":false,"given":"Mo\u2010Rong","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Forestry National Chung\u2010Hsing University  Taichung 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