{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:46:30Z","timestamp":1791945990086,"version":"4.3.4"},"reference-count":51,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"vor","delay-in-days":42,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["iubmb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioFactors"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Oral squamous cell carcinoma (OSCC) develops through a continuum of tissue states from chronic inflammation and potentially malignant lesions to invasive cancer, yet the dynamic remodeling of the oral immune microenvironment and its relevance to immunotherapy\u2010associated inflammation remain poorly understood. Here, we integrated single\u2010cell RNA sequencing, spatial transcriptomics, murine immunotherapy datasets, and experimental validation to characterize immune and stromal alterations across healthy mucosa, periodontitis, leukoplakia, and OSCC. This integrated analysis revealed distinct oral immune microenvironment states and identified condition\u2010associated neutrophil programs, including an S100A12\u2010enriched inflammatory state, an S100A14\u2010associated metabolic state in leukoplakia, and tumor\u2010associated neutrophil states in OSCC. Spatial analyses and cell\u2013cell communication modeling further nominated immune\u2013stromal interaction networks involving S100A12\n                    <jats:sup>+<\/jats:sup>\n                    neutrophils and fibroblast\u2010associated inflammatory signaling. A machine\u2010learning framework identified a nine\u2010gene Neu_S100A12\u2010associated signature that discriminated periodontitis\u2010associated inflammatory states across two retrospective cohorts, with seven concordantly upregulated genes prioritized for biological validation. Multiplex immunofluorescence and an IFN\u2010\u03b3\u2010primed OSCC inflammatory model provided experimental support for a TNF\u2010associated inflammatory phenotype linked to the S100A12 program. Together, these findings establish a cross\u2010sectional multi\u2010omics framework for defining oral immune states and identify S100A12\u2010associated neutrophil programs as candidate mediators of oral inflammation and immunotherapy\u2010related immune perturbation, providing a foundation for future prospective and mechanistic studies.\n                  <\/jats:p>","DOI":"10.1002\/biof.70157","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:27:42Z","timestamp":1791944862000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrated Single\u2010Cell and Spatial Multi\u2010Omics Reveal\n                    <scp>S100A12<\/scp>\n                    <sup>+<\/sup>\n                    Neutrophil Reprogramming Across Oral Inflammatory States and Immunotherapy\u2010Associated Perturbation"],"prefix":"10.1002","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7332-3259","authenticated-orcid":false,"given":"Chen","family":"Li","sequence":"first","affiliation":[{"name":"Department of Stomatology The First Affiliated Hospital of Naval Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Stomatology The First Affiliated Hospital of Naval Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwen","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Stomatology The First Affiliated Hospital of Naval Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuanyi","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Stomatology The First Affiliated Hospital of Naval Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhizen","family":"Quan","sequence":"additional","affiliation":[{"name":"Department of Stomatology The First Affiliated Hospital of Naval Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Stomatology The First Affiliated Hospital of Naval Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhao","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Stomatology The First Affiliated Hospital of Naval Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Stomatology The First Affiliated Hospital of Naval Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0329-6129","authenticated-orcid":false,"given":"Yibo","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Stomatology The First Affiliated Hospital of Naval Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaogang","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Stomatology The First Affiliated Hospital of Naval Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,13]]},"reference":[{"issue":"1","key":"e_1_2_12_2_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41698-024-00624-8","article-title":"A Fully Automated and Explainable Algorithm for Predicting Malignant Transformation in Oral Epithelial Dysplasia","volume":"8","author":"Shephard A. 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A.","year":"2023","journal-title":"Nature Reviews Clinical Oncology"},{"issue":"4","key":"e_1_2_12_4_1","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.70286","article-title":"PCIF1 Drives Oesophageal Squamous Cell Carcinoma Progression via m6Am\u2010Mediated Suppression of MTF2 Translation","volume":"15","author":"Li K.","year":"2025","journal-title":"Clinical and Translational Medicine"},{"key":"e_1_2_12_5_1","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2023-074962","article-title":"Advances in Diagnosis and Management of Cancer of the Esophagus","volume":"385","author":"Deboever N.","year":"2024","journal-title":"BMJ"},{"issue":"4","key":"e_1_2_12_6_1","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1002\/cncr.33984","article-title":"Long\u2010Term Outcomes in Patients With Advanced and\/or Metastatic Non\u2010Small Cell Lung Cancer Who Completed 2\u2009Years of Immune Checkpoint Inhibitors or Achieved a Durable Response After Discontinuation Without Disease Progression: Multicenter, Real\u2010World Data (KCSG LU20\u201011)","volume":"128","author":"Kim H.","year":"2022","journal-title":"Cancer"},{"issue":"5","key":"e_1_2_12_7_1","doi-asserted-by":"crossref","first-page":"388","DOI":"10.5306\/wjco.v13.i5.388","article-title":"Immune Checkpoint Inhibitors in Head and Neck Squamous Cell Carcinoma: A Systematic Review of Phase\u20103 Clinical Trials","volume":"13","author":"Poulose J. V.","year":"2022","journal-title":"World Journal of Clinical Oncology"},{"issue":"6","key":"e_1_2_12_8_1","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/S1470-2045(21)00136-4","article-title":"Pembrolizumab Plus Cetuximab in Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma: An Open\u2010Label, Multi\u2010Arm, Non\u2010Randomised, Multicentre, Phase 2 Trial","volume":"22","author":"Sacco A. G.","year":"2021","journal-title":"Lancet Oncology"},{"issue":"24","key":"e_1_2_12_9_1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms252413490","article-title":"Impact of T Cell Exhaustion and Stroma Senescence on Tumor Cell Biology and Clinical Outcome of Head and Neck Squamous Cell Carcinomas","volume":"25","author":"Brust L. A.","year":"2024","journal-title":"International Journal of Molecular Sciences"},{"issue":"5","key":"e_1_2_12_10_1","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1007\/s00520-017-3629-4","article-title":"Oral Mucosal Changes Induced by Anticancer Targeted Therapies and Immune Checkpoint Inhibitors","volume":"25","author":"Vigarios E.","year":"2017","journal-title":"Supportive Care in Cancer"},{"key":"e_1_2_12_11_1","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.1031519","article-title":"Circadian Clock\u2010A Promising Scientific Target in Oral Science","volume":"13","author":"Feng G.","year":"2022","journal-title":"Frontiers in Physiology"},{"key":"e_1_2_12_12_1","doi-asserted-by":"crossref","DOI":"10.3389\/froh.2021.740469","article-title":"Characterization of Oral Squamous Cell Carcinoma Associated Inflammation: A Pilot Study","volume":"2","author":"Laliberte C.","year":"2021","journal-title":"Frontiers in Oral Health"},{"issue":"5","key":"e_1_2_12_13_1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18051101","article-title":"Analysis of Gene Expression Signatures in Cancer\u2010Associated Stroma From Canine Mammary Tumours Reveals Molecular Homology to Human Breast Carcinomas","volume":"18","author":"Ettlin J.","year":"2017","journal-title":"International Journal of Molecular Sciences"},{"issue":"4","key":"e_1_2_12_14_1","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.it.2017.08.005","article-title":"Tissue\u2010Specific Immunity at the Oral Mucosal Barrier","volume":"39","author":"Moutsopoulos N. M.","year":"2018","journal-title":"Trends in Immunology"},{"key":"e_1_2_12_15_1","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.585502","article-title":"Hepatic Inflammation Confers Protective Immunity Against Liver Stages of Malaria Parasite","volume":"11","author":"Grand M.","year":"2020","journal-title":"Frontiers in Immunology"},{"issue":"6","key":"e_1_2_12_16_1","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1007\/s00262-022-03348-5","article-title":"Porphyromonas gingivalis\n                   Promotes the Progression of Oral Squamous Cell Carcinoma by Activating the Neutrophil Chemotaxis in the Tumour Microenvironment","volume":"72","author":"Guo Z. C.","year":"2023","journal-title":"Cancer Immunology, Immunotherapy"},{"issue":"1","key":"e_1_2_12_17_1","doi-asserted-by":"crossref","first-page":"168","DOI":"10.3390\/curroncol31010011","article-title":"Mechanisms and Potential Clinical Implications of Oral Microbiome in Oral Squamous Cell Carcinoma","volume":"31","author":"Wang J.","year":"2023","journal-title":"Current Oncology"},{"issue":"38","key":"e_1_2_12_18_1","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abd2712","article-title":"Revisiting the PD\u20101 Pathway","volume":"6","author":"Patsoukis N.","year":"2020","journal-title":"Science Advances"},{"issue":"4","key":"e_1_2_12_19_1","article-title":"Individualized Multimodal Immunotherapy (IMI): Scientific Rationale and Clinical Experience From a Single Institution","volume":"12","author":"Schirrmacher V.","year":"2024","journal-title":"Biomedicine"},{"issue":"13","key":"e_1_2_12_20_1","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.70685","article-title":"The Key Role of COA6 in Pancreatic Ductal Adenocarcinoma: Metabolic Reprogramming and Regulation of the Immune Microenvironment","volume":"29","author":"Jiang L.","year":"2025","journal-title":"Journal of Cellular and Molecular Medicine"},{"issue":"5","key":"e_1_2_12_21_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3892\/or.2025.8978","article-title":"Serum From Patients With Oral Squamous Cell Carcinoma Remodels the Tumor Immune Escape Ecological Niche by Promoting Regulatory T\u2010Cell Differentiation and T\u2010Cell Exhaustion","volume":"54","author":"Chen H.","year":"2025","journal-title":"Oncology Reports"},{"issue":"3","key":"e_1_2_12_22_1","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.ccell.2023.02.016","article-title":"The Evolving Tumor Microenvironment: From Cancer Initiation to Metastatic Outgrowth","volume":"41","author":"Visser K. 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W.","year":"2021","journal-title":"Cell"},{"issue":"2","key":"e_1_2_12_25_1","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/odi.14347","article-title":"Single\u2010Cell Transcriptomics Dissects Premalignant Progression in Proliferative Verrucous Leukoplakia","volume":"30","author":"Zhong L.","year":"2024","journal-title":"Oral Diseases"},{"issue":"12","key":"e_1_2_12_26_1","doi-asserted-by":"crossref","first-page":"4732","DOI":"10.1111\/cas.15979","article-title":"Single\u2010Cell Transcriptomic Analysis of Gingivo\u2010Buccal Oral Cancer Reveals Two Dominant Cellular Programs","volume":"114","author":"Kurkalang S.","year":"2023","journal-title":"Cancer Science"},{"key":"e_1_2_12_27_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.oraloncology.2021.105348","article-title":"Single\u2010Cell Profiling of Tumor\u2010Infiltrating TCF1\/TCF7(+) T Cells Reveals a T Lymphocyte Subset Associated With Tertiary Lymphoid Structures\/Organs and a Superior Prognosis in Oral Cancer","volume":"119","author":"Peng Y.","year":"2021","journal-title":"Oral Oncology"},{"issue":"9","key":"e_1_2_12_28_1","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1158\/1078-0432.CCR-23-3477","article-title":"Targeting Dendritic Cell Dysfunction to Circumvent Anti\u2010PD1 Resistance in Head and Neck Cancer","volume":"30","author":"Saito S.","year":"2024","journal-title":"Clinical Cancer Research"},{"issue":"9","key":"e_1_2_12_29_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.110854","article-title":"Smyd3\u2010Mediated Immuno\u2010Modulation in HPV\u2010Negative Head and Neck Squamous Cell Carcinoma Mouse Models","volume":"27","author":"Tsai D. E.","year":"2024","journal-title":"IScience"},{"key":"e_1_2_12_30_1","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.81525","article-title":"Spatially Resolved Transcriptomics Reveals Pro\u2010Inflammatory Fibroblast Involved in Lymphocyte Recruitment Through CXCL8 and CXCL10","volume":"12","author":"Caetano A. J.","year":"2023","journal-title":"eLife"},{"issue":"12","key":"e_1_2_12_31_1","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202306515","article-title":"Spatial Transcriptomic and Metabolomic Landscapes of Oral Submucous Fibrosis\u2010Derived Oral Squamous Cell Carcinoma and Its Tumor Microenvironment","volume":"11","author":"Zhi Y.","year":"2024","journal-title":"Advanced Science"},{"issue":"13","key":"e_1_2_12_32_1","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","article-title":"Integrated Analysis of Multimodal Single\u2010Cell Data","volume":"184","author":"Hao Y.","year":"2021","journal-title":"Cell"},{"key":"e_1_2_12_33_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-50194-3","article-title":"OmicVerse: A Framework for Bridging and Deepening Insights Across Bulk and Single\u2010Cell Sequencing","volume":"15","author":"Zeng Z.","year":"2024","journal-title":"Nature Communications"},{"issue":"4","key":"e_1_2_12_34_1","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.cels.2018.11.005","article-title":"Scrublet: Computational Identification of Cell Doublets in Single\u2010Cell Transcriptomic Data","volume":"8","author":"Wolock S. L.","year":"2019","journal-title":"Cell Systems"},{"issue":"12","key":"e_1_2_12_35_1","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1038\/s41592-019-0619-0","article-title":"Fast, Sensitive and Accurate Integration of Single\u2010Cell Data With Harmony","volume":"16","author":"Korsunsky I.","year":"2019","journal-title":"Nature Methods"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xinn.2021.100141"},{"key":"e_1_2_12_37_1","doi-asserted-by":"crossref","DOI":"10.1186\/s12864-018-4772-0","article-title":"Slingshot: Cell Lineage and Pseudotime Inference for Single\u2010Cell Transcriptomics","volume":"19","author":"Street K.","year":"2018","journal-title":"BMC Genomics"},{"issue":"1","key":"e_1_2_12_38_1","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/s41467-021-21246-9","article-title":"Inference and Analysis of Cell\u2010Cell Communication Using CellChat","volume":"12","author":"Jin S.","year":"2021","journal-title":"Nature Communications"},{"issue":"2","key":"e_1_2_12_39_1","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/s41592-019-0667-5","article-title":"NicheNet: Modeling Intercellular Communication by Linking Ligands to Target Genes","volume":"17","author":"Browaeys R.","year":"2020","journal-title":"Nature Methods"},{"issue":"4","key":"e_1_2_12_40_1","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/s41587-021-01091-3","article-title":"Identifying Phenotype\u2010Associated Subpopulations by Integrating Bulk and Single\u2010Cell Sequencing Data","volume":"40","author":"Sun D.","year":"2022","journal-title":"Nature Biotechnology"},{"issue":"11","key":"e_1_2_12_41_1","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1902\/jop.2008.080139","article-title":"Transcriptomes in Healthy and Diseased Gingival Tissues","volume":"79","author":"Demmer R. T.","year":"2008","journal-title":"Journal of Periodontology"},{"issue":"5","key":"e_1_2_12_42_1","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1177\/0022034514527288","article-title":"Gingival Tissue Transcriptomes Identify Distinct Periodontitis Phenotypes","volume":"93","author":"Kebschull M.","year":"2014","journal-title":"Journal of Dental Research"},{"issue":"1","key":"e_1_2_12_43_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41420-024-01895-7","article-title":"Dual Inhibitors of DNMT and HDAC Induce Viral Mimicry to Induce Antitumour Immunity in Breast Cancer","volume":"10","author":"Huang W.","year":"2024","journal-title":"Cell Death Discovery"},{"issue":"7737","key":"e_1_2_12_44_1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/s41586-018-0768-9","article-title":"Loss of ADAR1 in Tumours Overcomes Resistance to Immune Checkpoint Blockade","volume":"565","author":"Ishizuka J. J.","year":"2019","journal-title":"Nature"},{"issue":"11","key":"e_1_2_12_45_1","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1038\/s41416-020-0820-z","article-title":"Diagnostic Value of (18)F\u2010FDG\u2010PET to Predict the Tumour Immune Status Defined by Tumoural PD\u2010L1 and CD8(+)tumour\u2010Infiltrating Lymphocytes in Oral Squamous Cell Carcinoma","volume":"122","author":"Togo M.","year":"2020","journal-title":"British Journal of Cancer"},{"key":"e_1_2_12_46_1","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2025.1502073","article-title":"The Immunological Landscape of CCL26(High) Invasive Oral Squamous Cell Carcinoma","volume":"13","author":"Liu L.","year":"2025","journal-title":"Frontiers in Cell and Developmental Biology"},{"issue":"6","key":"e_1_2_12_47_1","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2021-002434","article-title":"Immune Landscape and Subtypes in Primary Resectable Oral Squamous Cell Carcinoma: Prognostic Significance and Predictive of Therapeutic Response","volume":"9","author":"Diao P.","year":"2021","journal-title":"Journal for Immunotherapy of Cancer"},{"issue":"1","key":"e_1_2_12_48_1","doi-asserted-by":"crossref","DOI":"10.1186\/s40246-024-00712-7","article-title":"Integrating Single\u2010Cell RNA\u2010Seq and Bulk RNA\u2010Seq to Construct a Neutrophil Prognostic Model for Predicting Prognosis and Immune Response in Oral Squamous Cell Carcinoma","volume":"18","author":"Wang J.","year":"2024","journal-title":"Human Genomics"},{"issue":"12","key":"e_1_2_12_49_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e22596","article-title":"The Role of PDIA3 in Oral Squamous Cell Carcinoma and Its Value as A Diagnostic and Prognostic Biomarker","volume":"9","author":"Wang L.","year":"2023","journal-title":"Heliyon"},{"issue":"1","key":"e_1_2_12_50_1","doi-asserted-by":"crossref","DOI":"10.1186\/s12903-023-02936-w","article-title":"CD79A Work as a Potential Target for the Prognosis of Patients With OSCC: Analysis of Immune Cell Infiltration in Oral Squamous Cell Carcinoma Based on the CIBERSORTx Deconvolution Algorithm","volume":"23","author":"Yao S.","year":"2023","journal-title":"BMC Oral Health"},{"issue":"15","key":"e_1_2_12_51_1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26157401","article-title":"S100A14 as a Potential Biomarker of the Colorectal Serrated Neoplasia Pathway","volume":"26","author":"Adam P.","year":"2025","journal-title":"International Journal of Molecular Sciences"},{"issue":"11","key":"e_1_2_12_52_1","doi-asserted-by":"crossref","first-page":"134","DOI":"10.14715\/cmb\/2024.70.11.20","article-title":"The Emerging Role of S100A4 and S100A14 Proteins in Colorectal Cancer Progression","volume":"70","author":"Rasool S.","year":"2024","journal-title":"Cellular and Molecular Biology (Noisy\u2010le\u2010Grand, France)"}],"container-title":["BioFactors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/iubmb.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/biof.70157","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iubmb.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/biof.70157","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iubmb.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/biof.70157","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:27:55Z","timestamp":1791944875000},"score":1,"resource":{"primary":{"URL":"https:\/\/iubmb.onlinelibrary.wiley.com\/doi\/10.1002\/biof.70157"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":51,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/biof.70157"],"URL":"https:\/\/doi.org\/10.1002\/biof.70157","archive":["Portico"],"relation":{},"ISSN":["0951-6433","1872-8081"],"issn-type":[{"value":"0951-6433","type":"print"},{"value":"1872-8081","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"2026-05-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70157"}}