{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T02:49:35Z","timestamp":1791514175546,"version":"4.3.4"},"reference-count":137,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":37,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["iubmb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioFactors"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Marine\u2010derived collagen (MDC) represents a sustainable source of bioactive biomolecules derived from marine processing by\u2010products, with emerging applications in molecular nutrition and healthy aging. Compared with mammalian collagen, MDC exhibits distinctive structural characteristics, including variable imino acid composition, reduced thermal stability, and enhanced enzymatic accessibility, which determine its physicochemical properties, processing behavior, and biological potential. These structural features also underpin the distinct functional roles of native collagen and collagen\u2010derived peptides: intact MDC retains triple\u2010helical architectures and extracellular matrix\u2010interactive motifs that support cellular responses and tissue homeostasis, whereas hydrolyzed marine collagen peptides (MCPs) are orally administered bioactive peptides that can undergo gastrointestinal absorption and have been investigated for potential systemic health effects. This review summarizes current advances in the molecular characteristics, sustainable production, structural modification, and biological functions of MDC and MCPs, emphasizing the structure\u2013function relationships that govern their nutritional and physiological effects. We discuss how extraction and processing strategies regulate collagen architecture, peptide generation, and bioactivity, and further examine the molecular mechanisms that have been proposed to underlie the antioxidant, anti\u2010inflammatory, metabolic regulatory, and musculoskeletal protective effects of MCPs. Particular attention is given to aging\u2010associated physiological decline, in which oxidative stress, chronic inflammation, and extracellular matrix deterioration contribute to impaired tissue homeostasis. Emerging experimental evidence suggests that marine collagen\u2010derived bioactive peptides may modulate key signaling pathways, including Nrf2\u2010mediated antioxidant responses, NF\u2010\u03baB\u2010related inflammatory regulation, and pathways involved in connective tissue remodeling and metabolic balance. Finally, we highlight current challenges limiting the broader application of MDC\u2010derived biofactors, including source variability, structural and compositional standardization, bioavailability characterization, and the need for well\u2010designed human studies. By integrating marine sustainability, molecular structure, and biological function, MDC and its derived peptides may serve as promising food\u2010derived biofactors with potential applications in supporting healthy aging and age\u2010related health maintenance.<\/jats:p>","DOI":"10.1002\/biof.70159","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T02:16:41Z","timestamp":1791512201000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Marine\u2010Derived Collagen Peptides as Emerging Biofactors: Molecular Characteristics, Biological Mechanisms, and Potential Roles in Healthy Aging"],"prefix":"10.1002","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8889-9433","authenticated-orcid":false,"given":"Huijie","family":"Wu","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Macau University of Science and Technology  Macau China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Dong","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Macau University of Science and Technology  Macau China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7654-2557","authenticated-orcid":false,"given":"Shaotao","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Pancreato\u2010Biliary Surgery The First Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8212-1097","authenticated-orcid":false,"given":"Lewei","family":"Tu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Macau University of Science and Technology  Macau China"},{"name":"School of Nursing, Zhejiang Chinese Medical University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5648-6802","authenticated-orcid":false,"given":"Xiaoyu","family":"Tao","sequence":"additional","affiliation":[{"name":"Faculty of Innovative Hospitality Management, Macau University of Tourism  Macau China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixian","family":"Wu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Macau University of Science and Technology  Macau China"},{"name":"Department of Health Management The First People's Hospital of Foshan  Foshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Ai","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Macau University of Science and Technology  Macau China"},{"name":"Department of Management, Gongbei Community Health Service Center Zhuhai Hospital of Integrated Traditional Chinese and Western Medicine  Zhuhai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9171-269X","authenticated-orcid":false,"given":"Quancai","family":"Sun","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Macau University of Science and Technology  Macau China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Xiao","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Macau University of Science and Technology  Macau China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9809-4719","authenticated-orcid":false,"given":"Ye","family":"Peng","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Macau University of Science and Technology  Macau China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,8]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2026.118982","article-title":"Collagen Peptides From Marine By\u2010Products: From Waste to Functional Ingredients","volume":"233","author":"Ashaolu T. 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