{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T04:39:13Z","timestamp":1792557553803,"version":"4.5.0"},"reference-count":47,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:00:00Z","timestamp":1792454400000},"content-version":"vor","delay-in-days":49,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["iubmb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioFactors"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Advanced prostate cancer metastasizes primarily to bone, a process driven in part by the de novo expression of bone\u2010associated factors (osteomimicry) that enables tumor cells to colonize and thrive in the skeletal environment. During the early stages of tumorigenesis in multiple cancer types, the primary cilium, a non\u2010motile microtubule\u2010based sensory organelle, is lost. However, the causes of primary cilium loss and the consequences of this process for tumor progression are still ill\u2010defined. The aim of this study was to determine whether MINDIN, a protein secreted by prostate tumor cells, promotes primary cilium reduction and osteomimicry, thereby enhancing the ability of prostate cancer cells to colonize bone. We observed that upregulation of MINDIN decreased the levels of the primary cilia marker Ift88 in association with the overexpression of\n                    <jats:italic>Pth1r<\/jats:italic>\n                    ,\n                    <jats:italic>Pthlh<\/jats:italic>\n                    , and other osteomimicry\u2010related genes in an in\u00a0vivo mouse pre\u2010metastatic prostate cancer model. Stimulation with MINDIN decreased primary cilia presence and length and promoted tumor cell osteomimicry, proliferation, and migration; processes similarly induced in primary cilia\u2010inhibited adenocarcinoma prostate cells. Ablation of\n                    <jats:italic>Pth1r<\/jats:italic>\n                    inhibited the effects of both MINDIN and primary cilium loss on prostate cancer cell osteomimicry, proliferation, and migration. Furthermore,\n                    <jats:italic>Pth1r<\/jats:italic>\n                    overexpression and\n                    <jats:italic>Ift88<\/jats:italic>\n                    downregulation were associated with enhanced tumor cell growth in an ex\u00a0vivo bone mouse model. Collectively, these findings indicate that MINDIN induces primary cilia attenuation leading to activation of PTH1R, thereby driving osteomimicry and facilitating prostate cancer cell colonization of bone.\n                  <\/jats:p>","DOI":"10.1002\/biof.70164","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T03:49:01Z","timestamp":1792554541000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["MINDIN\u2010Induced Attenuation of Primary Cilia Activates Parathyroid Hormone Receptor Type I (PTH1R) to Drive Osteomimicry and Bone Tropism in Prostate Cancer"],"prefix":"10.1002","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9686-672X","authenticated-orcid":false,"given":"Luis","family":"\u00c1lvarez\u2010Carri\u00f3n","sequence":"first","affiliation":[{"name":"CANMET Research Group, Instituto de Medicina Molecular Aplicada (IMMA) Universidad San Pablo\u2010CEU, CEU Universities ES, Urbanizaci\u00f3n Montepr\u00edncipe  Madrid Spain"},{"name":"Departamento de Ciencias M\u00e9dicas B\u00e1sicas, Facultad de Medicina Universidad San Pablo\u2010CEU, CEU Universities, Urbanizaci\u00f3n Montepr\u00edncipe  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Lozano\u2010Bustos","sequence":"additional","affiliation":[{"name":"CANMET Research Group, Instituto de Medicina Molecular Aplicada (IMMA) Universidad San Pablo\u2010CEU, CEU Universities ES, Urbanizaci\u00f3n Montepr\u00edncipe  Madrid Spain"},{"name":"Departamento de Ciencias M\u00e9dicas B\u00e1sicas, Facultad de Medicina Universidad San Pablo\u2010CEU, CEU Universities, Urbanizaci\u00f3n Montepr\u00edncipe  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Guti\u00e9rrez\u2010Rojas","sequence":"additional","affiliation":[{"name":"CANMET Research Group, Instituto de Medicina Molecular Aplicada (IMMA) Universidad San Pablo\u2010CEU, CEU Universities ES, Urbanizaci\u00f3n Montepr\u00edncipe  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5897-8165","authenticated-orcid":false,"given":"Martina","family":"Romeo","sequence":"additional","affiliation":[{"name":"CANMET Research Group, Instituto de Medicina Molecular Aplicada (IMMA) Universidad San Pablo\u2010CEU, CEU Universities ES, Urbanizaci\u00f3n Montepr\u00edncipe  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5072-3141","authenticated-orcid":false,"given":"Arancha R.","family":"Gort\u00e1zar","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias M\u00e9dicas B\u00e1sicas, Facultad de Medicina Universidad San Pablo\u2010CEU, CEU Universities, Urbanizaci\u00f3n Montepr\u00edncipe  Madrid Spain"},{"name":"Bone Physiopathology Laboratory, Instituto de Medicina Molecular Aplicada (IMMA). Facultad de Medicina Universidad San Pablo\u2010CEU, CEU Universities, Urbanizaci\u00f3n Montepr\u00edncipe  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2813-3257","authenticated-orcid":false,"given":"Ver\u00f3nica","family":"Alonso","sequence":"additional","affiliation":[{"name":"CANMET Research Group, Instituto de Medicina Molecular Aplicada (IMMA) Universidad San Pablo\u2010CEU, CEU Universities ES, Urbanizaci\u00f3n Montepr\u00edncipe  Madrid Spain"},{"name":"Departamento de Ciencias M\u00e9dicas B\u00e1sicas, Facultad de Medicina Universidad San Pablo\u2010CEU, CEU Universities, Urbanizaci\u00f3n Montepr\u00edncipe  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2827-3364","authenticated-orcid":false,"given":"Juan A.","family":"Ardura","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias M\u00e9dicas B\u00e1sicas, Facultad de Medicina Universidad San Pablo\u2010CEU, CEU Universities, Urbanizaci\u00f3n Montepr\u00edncipe  Madrid Spain"},{"name":"Bone Physiopathology Laboratory, Instituto de Medicina Molecular Aplicada (IMMA). 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