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Perturbations of homocysteine metabolism, particularly intracellular and subsequently circulating accumulation of homocysteine (<jats:italic>i.e<\/jats:italic>., hyperhomocysteinemia), are associated with vascular disease risk, as well as other pathologies. However, intervention with B\u2010vitamin supplementation has been shown to successfully restore normal homocysteine concentrations, but without concomitant reductions in disease risk. Thus, the mechanistic relation between homocysteine balance and disease states, as well as the value of homocysteine management, remains an area of intense investigation.<\/jats:p>","DOI":"10.1002\/biof.71","type":"journal-article","created":{"date-parts":[[2010,1,20]],"date-time":"2010-01-20T13:39:56Z","timestamp":1263994796000},"page":"19-24","source":"Crossref","is-referenced-by-count":98,"title":["Homocysteine metabolism and its relation to health and disease"],"prefix":"10.1002","volume":"36","author":[{"given":"Kelly T.","family":"Williams","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin L.","family":"Schalinske","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,1,20]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/9780470475973.ch5"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)45067-9"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-349-06343-7_1"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4613-3045-5_6"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1042\/cs0810551"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(75)90040-2"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(80)90192-4"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/83.1.5"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/85.1.19"},{"key":"e_1_2_7_11_2","doi-asserted-by":"crossref","first-page":"E1095","DOI":"10.1152\/ajpendo.2001.281.5.E1095","article-title":"Methylation demand and homocysteine metabolism: effects of dietary provision of creatine and guanidinoacetate","volume":"281","author":"Stead L. 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