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Since RNA research has made great progress in recent years here we present an overview of studies demonstrating the role of various non\u2010coding RNAs in neurodegeneration and stress response in <jats:italic>Drosophila<\/jats:italic> as a model organism. We put special emphasis on the role of non\u2010coding micro RNAs, hsr\u2010omega transcripts, and artificial small highly structured RNAs as triggers of neuropathology including aggregates formation, cognitive abnormalities and other symptoms. Cellular stress is a conspicuous feature of many neurodegenerative diseases and the production of specialized proteins protects the nerve cells against aggregates formation. Therefore, herein we describe some data implicating various classes of non\u2010coding RNAs in stress response in <jats:italic>Drosophila<\/jats:italic>. All these findings highlight <jats:italic>Drosophila<\/jats:italic> as an important model system to investigate various brain diseases potentially mediated by some non\u2010coding RNAs including polyglutamine diseases, Alzheimer's disease, Huntigton's disease, and many others.<\/jats:p>","DOI":"10.1002\/biot.200800120","type":"journal-article","created":{"date-parts":[[2008,8,13]],"date-time":"2008-08-13T07:03:17Z","timestamp":1218610997000},"page":"1010-1021","source":"Crossref","is-referenced-by-count":5,"title":["Role of non\u2010coding RNAs in neurodegeneration and stress response in <i>Drosophila<\/i>"],"prefix":"10.1002","volume":"3","author":[{"given":"Elena","family":"Savvateeva\u2010Popova","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Medvedeva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrei","family":"Popov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Evgen'ev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,8,13]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00177-5"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.72.2.152"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-211-45295-0_18"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-006-0513-7"},{"key":"e_1_2_1_6_2","first-page":"543","article-title":"Gene expression profiling of parkinsonian substantia nigra pars compacta; alterations in ubiquitin\u2010proteasome, heat shock protein, iron and oxidative stress regulated proteins, cell adhesion\/cellular matrix and vesicle trafficking genes.","volume":"111","author":"G\u00fcnblatt E.","year":"2004","journal-title":"J. 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