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To address this question, the present review deals with the induction of an unique <jats:italic>O<\/jats:italic>\u2010acetyl derivative of sialic acid on a few disease\u2010associated glycoproteins and glycolipids at the onset of childhood ALL, a finding of our group in the last decade. This information has been successfully utilized for diagnosis and prognosis of the disease. Existing literature is included for comparison. Additionally, cell surface overexpression of 9\u2010<jats:italic>O<\/jats:italic>\u2010acetylated sialoglycoproteins and antibodies against them present in patients' sera aid the survival of the malignant lymphoblasts and suggest a multifaceted role played by these molecules. Taken together, monitoring these molecules helps not only in unravelling the biology of this paediatric malignancy but also in personalizing the treatment strategies for the betterment of the patient population.<\/jats:p>","DOI":"10.1002\/biot.200800253","type":"journal-article","created":{"date-parts":[[2009,3,18]],"date-time":"2009-03-18T03:25:36Z","timestamp":1237346736000},"page":"361-374","source":"Crossref","is-referenced-by-count":13,"title":["<i>O<\/i>\u2010acetylated sialic acids: Multifaceted role in childhood acute lymphoblastic leukaemia"],"prefix":"10.1002","volume":"4","author":[{"given":"Suchandra","family":"Chowdhury","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chitra","family":"Mandal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,3,18]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1182\/blood.V73.8.2051.2051","article-title":"Acute lymphoblastic leukemia: Recent advances in biology and therapy.","volume":"73","author":"Champlin R.","year":"1989","journal-title":"Blood"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60457-2"},{"key":"e_1_2_1_4_2","first-page":"4752","article-title":"Analysis of the clinical and biological significance of lymphoid phenotypes in acute leukemia.","volume":"41","author":"Greaves M. 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