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The basics of this therapeutic approach lie in the regulation property of sphingolipids on cellular processes, which are important in a cell's fate, such as cell proliferation, apoptosis, cell cycle arrest, senescence, and inflammation. Furthermore, the mutations in the enzymes catalyzing some specific reactions in the sphingolipid metabolism cause mortal lysosomal storage diseases like Fabry, Gaucher, Niemann\u2010Pick, Farber, Krabbe, and Metachromatic Leukodystrophy. Therefore, the alteration of the sphingolipid metabolic pathway determines the choice between life and death. Understanding the sphingolipid metabolism and regulation is significant for the development of new therapeutic approaches for all sphingolipid\u2010related diseases, as well as for cancer. An important feature of the sphingolipid metabolic pathway is the compartmentalization into endoplasmic reticulum, the Golgi apparatus, lysosome and plasma membrane, and this compartmentalization makes the transport of sphingolipids critical for proper functioning. This paper focuses on the structures, metabolic pathways, localization, transport mechanisms, and diseases of sphingolipids in <jats:italic>Saccharomyces cerevisiae<\/jats:italic> and humans, and provides the latest comprehensive information on sphingolipid research.<\/jats:p>","DOI":"10.1002\/biot.200800322","type":"journal-article","created":{"date-parts":[[2009,7,3]],"date-time":"2009-07-03T09:42:15Z","timestamp":1246614135000},"page":"1028-1041","source":"Crossref","is-referenced-by-count":25,"title":["Molecular facets of sphingolipids: Mediators of diseases"],"prefix":"10.1002","volume":"4","author":[{"given":"Fatma Betul Kavun","family":"Ozbayraktar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kutlu O.","family":"Ulgen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,7,17]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2006.08.052"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R800003-JLR200"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-05-0420"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R200008200"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2005.04.006"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-1981(99)00068-2"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-1981(02)00210-X"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-1981(02)00132-4"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtbi.2003.08.010"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1139\/o03-086"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2006.08.005"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2006.08.007"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2005.04.001"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600562"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.46.30550"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi026616d"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1411"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2007.01.009"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2006.05.027"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-1981(00)00054-8"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1023\/B:NERE.0000021232.05175.38"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0962-8924(02)02399-1"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0854.2000.011101.x"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2003.1275"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.197702733"},{"key":"e_1_2_1_27_2","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1093\/clinchem\/13.7.565","article-title":"Enzymatic abnormalities in diseases of sphingolipid metabolism.","volume":"14","author":"Brady R.","year":"1967","journal-title":"Clin. 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