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We conducted proof\u2010of\u2010concept experiments aimed at assessing efficacy upon oral administration of a novel combination therapy for central pattern generator (CPG) activation and corresponding locomotor movement generation in completely paraplegic animals. Co\u2010administration orally (by gavage) of buspirone, levodopa and carbidopa was found to dose\u2010dependently induce episodes of steady weight\u2010bearing stepping in low\u2010thoracic (Th9\/10) spinal cord\u2010transected (Tx) mice (with no other form of assistance or training). Robust hindlimb stepping with weight\u2010bearing capabilities was induced with the tri\u2010therapy but not with clinically relevant doses of these compounds administered separately. These results provide evidence suggesting that this drug combination may be ideally suited to constitute a first\u2010in\u2010class therapy (CPG activator) for locomotor activity induction in chronic SCI individuals, given that efficacy was shown using commercially available brain\u2010permeable small molecules, already known as safe for the treatment of various neurological indications.<\/jats:p>","DOI":"10.1002\/biot.200900278","type":"journal-article","created":{"date-parts":[[2010,3,26]],"date-time":"2010-03-26T14:28:16Z","timestamp":1269613696000},"page":"421-426","source":"Crossref","is-referenced-by-count":28,"title":["Oral administration of a tri\u2010therapy for central pattern generator activation in paraplegic mice: Proof\u2010of\u2010concept of efficacy"],"prefix":"10.1002","volume":"5","author":[{"given":"Pierre A.","family":"Guertin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roth\u2010Visal","family":"Ung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Rouleau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,3,26]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/10400435.1999.10131993"},{"key":"e_1_2_1_3_2","first-page":"3","article-title":"Anemia in acute phase of spinal cord injury.","volume":"71","author":"Huang C. 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