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Biopharmaceuticals produced in plants are inexpensive to produce, require fewer expensive purification steps, and can be stored at ambient temperatures for prolonged periods of time. As a result, plant\u2010produced biopharmaceuticals have the potential to be more accessible to the rural poor. This review describes current progress with respect to plant\u2010produced biopharmaceuticals, with a particular emphasis on those that target developing countries. Specific emphasis is given to recent research on the production of plant\u2010produced vaccines toward human immunodeficiency virus, malaria, tuberculosis, hepatitis B virus, Ebola virus, human papillomavirus, rabies virus and common diarrheal diseases. Production platforms used to express vaccines in plants, including nuclear and chloroplast transformation, and the use of viral expression vectors, are described in this review. The review concludes by outlining the next steps for plant\u2010produced vaccines to achieve their goal of providing safe, efficacious and inexpensive vaccines to the developing world.<\/jats:p>","DOI":"10.1002\/biot.201300162","type":"journal-article","created":{"date-parts":[[2013,7,15]],"date-time":"2013-07-15T09:36:55Z","timestamp":1373881015000},"page":"1193-1202","source":"Crossref","is-referenced-by-count":51,"title":["Plant\u2010derived pharmaceuticals for the developing world"],"prefix":"10.1002","volume":"8","author":[{"given":"Kathleen","family":"Hefferon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,7,15]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/81132"},{"key":"e_1_2_7_3_2","unstructured":"United Nations The Millennium Development Goals Report 2010. 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