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The sub\u2010cortical region of the forebrain is associated with the control of movement and behavior, thus HD initially presents with coordination difficulty and cognitive decline. Recent reprogramming technologies, including induced pluripotent stem cells (iPSCs) and induced neural stem cells (iNSCs), have created opportunities to understand the pathological cascades that underlie HD and to develop new treatments for this currently incurable neurological disease. The ultimate objectives of stem cell\u2010based therapies for HD are to replace lost neurons and to prevent neuronal dysfunction and death. In this review, we examine the current understanding of the molecular and pathological mechanisms involved in HD. We discuss disease modeling with HD\u2010iPSCs derived from the somatic cells of patients, which could provide an invaluable platform for understanding HD pathogenesis. We speculate about the benefits and drawbacks of using iNSCs as an alternative stem cell source for HD treatment. Finally, we discuss cell culture and engineering systems that promote the directed differentiation of pluripotent stem cell\u2010derived NSCs into a striatal DARPP32<jats:sup>+<\/jats:sup> GABAergic MSN phenotype for HD. In conclusion, this review summarizes the potentials of cell reprogramming and engineering technologies relevant to the development of cell\u2010based therapies for HD.<\/jats:p>","DOI":"10.1002\/biot.201300560","type":"journal-article","created":{"date-parts":[[2014,5,15]],"date-time":"2014-05-15T05:14:15Z","timestamp":1400130855000},"page":"882-894","source":"Crossref","is-referenced-by-count":12,"title":["Stem cell therapy and cellular engineering for treatment of neuronal dysfunction in Huntington's disease"],"prefix":"10.1002","volume":"9","author":[{"given":"Kyung\u2010Ah","family":"Choi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Insik","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hang\u2010soo","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung\u2010Ick","family":"Oh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seongman","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunghoi","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,5,15]]},"reference":[{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198611133152006"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrg1686"},{"key":"e_1_2_9_4_2","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1139\/jpn.0603","article-title":"Brain imaging and cognitive dysfunctions in Huntington's disease.","volume":"31","author":"Montoya A.","year":"2006","journal-title":"J. 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