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Specifically, iPSC technology has aided the study and treatment of early\u2010onset pediatric neurodegenerative diseases such as Rett syndrome, Down syndrome, Angelman syndrome. Prader\u2013Willi syndrome, Friedreich's ataxia, spinal muscular atrophy (SMA), fragile X syndrome, X\u2010linked adrenoleukodystrophy (ALD), and <jats:italic>SCN1A<\/jats:italic> gene\u2010related epilepsies. 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