{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T04:50:51Z","timestamp":1793163051038,"version":"4.5.0"},"reference-count":117,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,3,20]],"date-time":"2015-03-20T00:00:00Z","timestamp":1426809600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biotechnology Journal"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The baculovirus expression vector system (BEVS) platform has become an established manufacturing platform for the production of viral vaccines and gene therapy vectors. Nine BEVS\u2010derived products have been approved \u2013 four for human use (Cervarix\u00ae, Provenge\u00ae, Glybera\u00ae and Flublok\u00ae) and five for veterinary use (Porcilis\u00ae Pesti, BAYOVAC CSF E2\u00ae, Circumvent\u00ae PCV, Ingelvac CircoFLEX\u00ae and Porcilis\u00ae PCV). The BEVS platform offers many advantages, including manufacturing speed, flexible product design, inherent safety and scalability. This combination of features and product approvals has previously attracted interest from academic researchers, and more recently from industry leaders, to utilize BEVS to develop next generation vaccines, vectors for gene therapy, and other biopharmaceutical complex proteins. In this review, we explore the BEVS platform, detailing how it works, platform features and limitations and important considerations for manufacturing and regulatory approval. To underscore the growth in opportunities for BEVS\u2010derived products, we discuss the latest product developments in the gene therapy and influenza vaccine fields that follow in the wake of the recent product approvals of Glybera\u00ae and Flublok\u00ae, respectively. We anticipate that the utility of the platform will expand even further as new BEVS\u2010derived products attain licensure. Finally, we touch on some of the areas where new BEVS\u2010derived products are likely to emerge.<\/jats:p>","DOI":"10.1002\/biot.201400438","type":"journal-article","created":{"date-parts":[[2015,3,20]],"date-time":"2015-03-20T12:26:33Z","timestamp":1426854393000},"page":"702-714","source":"Crossref","is-referenced-by-count":252,"title":["The baculovirus expression vector system: A commercial manufacturing platform for viral vaccines and gene therapy vectors"],"prefix":"10.1002","volume":"10","author":[{"given":"Rachael S.","family":"Felberbaum","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,20]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.01.016"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-3527(06)68006-8"},{"key":"e_1_2_8_4_2","unstructured":"Cox M. M. Commercial production in insect cells. 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