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The photothrombotic ischemia model, based on the intravascular photochemical reaction, is widely used for in vivo studies. However, this study has limitations, which generated a relatively small\u2010sized infarction model on superficial cortex compared to that of the MCAO stroke model. In this study, the photothorombosis mouse model is adapted and the optimum conditions for generation of cell death and deficits with high reproducibility is determined. The extent of damage within the cortex was assessed by infarct volume and cellular\/behavioral analyses. In this model, the neural cell death and inflammatory responses is detected; moreover, the degree of behavioral impairment is correlated with the brain infarct volume. Further, to enhance the understanding of neural repair, the effect of neural differentiation by transplantation of human bone marrow\u2010derived mesenchymal stem cells (BM\u2010MSCs) is analyzed. The authors demonstrated that transplantation of BM\u2010MSCs promoted the neural differentiation and behavioral performance in their photothrombosis model. Therefore, this research was meaningful to provide a stable animal model of stroke with low variability. Moreover, this model will facilitate development of novel MSC\u2010based therapeutics for stroke.<\/jats:p>","DOI":"10.1002\/biot.201600057","type":"journal-article","created":{"date-parts":[[2016,7,21]],"date-time":"2016-07-21T07:07:09Z","timestamp":1469084829000},"page":"1397-1404","source":"Crossref","is-referenced-by-count":23,"title":["Effect of human mesenchymal stem cell transplantation on cerebral ischemic volume\u2010controlled photothrombotic mouse model"],"prefix":"10.1002","volume":"11","author":[{"given":"Yun\u2010Kyong","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Medical Biotechnology Dongguk University  Gyeonggi\u2010do Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enerelt","family":"Urnukhsaikhan","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnology Dongguk University  Gyeonggi\u2010do Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee\u2010Hoon","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnology Dongguk University  Gyeonggi\u2010do Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young\u2010Kwon","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnology Dongguk University  Gyeonggi\u2010do Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung\u2010Keug","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnology Dongguk University  Gyeonggi\u2010do Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,10,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60694-7"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1999.79.4.1431"},{"key":"e_1_2_8_4_1","first-page":"3445","article-title":"Animal models of ischemic stroke and their application in clinical research","volume":"9","author":"Fluri F.","year":"2015","journal-title":"Drug Des. 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