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Due to their high foaming capacity in aerated bioreactor, the development of scalable bioprocesses for their production is a major bottleneck. In addition, the genes involved in the biosynthesis of these lipopeptides are mainly regulated by the quorum sensing, a global regulatory mechanism depending on cell density and known to be activated in biofilms. Several approaches have thus been considered in literature taking into account two criteria, on one side, to favor, control or avoid foam formation and on the other side, to use planktonic or immobilized (biofilm) cells. These different bioprocesses are discussed in the present review along with the purification strategies proposed for extracting and concentrating these biosurfactants.<\/jats:p>","DOI":"10.1002\/biot.201600566","type":"journal-article","created":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T07:56:49Z","timestamp":1498031809000},"source":"Crossref","is-referenced-by-count":76,"title":["Microbial lipopeptide production and purification bioprocesses, current progress and future challenges"],"prefix":"10.1002","volume":"12","author":[{"given":"Fran\u00e7ois","family":"Coutte","sequence":"first","affiliation":[{"name":"Institut Charles Viollette, Universit\u00e9 Lille, INRA, ISA, Universit\u00e9 d'Artois Universit\u00e9 Littoral C\u00f4te d'Opale  EA 7394\u2010ICV Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Lecouturier","sequence":"additional","affiliation":[{"name":"Institut Charles Viollette, Universit\u00e9 Lille, INRA, ISA, Universit\u00e9 d'Artois Universit\u00e9 Littoral C\u00f4te d'Opale  EA 7394\u2010ICV Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krasimir","family":"Dimitrov","sequence":"additional","affiliation":[{"name":"Institut Charles Viollette, Universit\u00e9 Lille, INRA, ISA, Universit\u00e9 d'Artois Universit\u00e9 Littoral C\u00f4te d'Opale  EA 7394\u2010ICV Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010S\u00e9bastien","family":"Guez","sequence":"additional","affiliation":[{"name":"Institut Charles Viollette, Universit\u00e9 Lille, INRA, ISA, Universit\u00e9 d'Artois Universit\u00e9 Littoral C\u00f4te d'Opale  EA 7394\u2010ICV Lille France"},{"name":"Axe GePEB, Institut Pascal, UMR 6602 Universit\u00e9 Clermont Auvergne, CNRS, SIGMA  Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Delvigne","sequence":"additional","affiliation":[{"name":"Microbial Processes and Interactions, TERRA Teaching and Research Centre Gembloux Agro\u2010Bio Tech University of Liege  Gembloux Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Dhulster","sequence":"additional","affiliation":[{"name":"Institut Charles Viollette, Universit\u00e9 Lille, INRA, ISA, Universit\u00e9 d'Artois Universit\u00e9 Littoral C\u00f4te d'Opale  EA 7394\u2010ICV Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Jacques","sequence":"additional","affiliation":[{"name":"Institut Charles Viollette, Universit\u00e9 Lille, INRA, ISA, Universit\u00e9 d'Artois Universit\u00e9 Littoral C\u00f4te d'Opale  EA 7394\u2010ICV Lille France"},{"name":"Microbial Processes and Interactions, TERRA Teaching and Research Centre Gembloux Agro\u2010Bio Tech University of Liege  Gembloux Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,21]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"57","volume-title":"Microbiology Monographs","author":"Jacques P.","year":"2011"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv1143"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/biot.201400541"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0927-7757(98)00627-X"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/bp070032r"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/aem.42.3.408-412.1981"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0141-0229(00)00327-6"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.procbio.2006.03.027"},{"key":"e_1_2_9_10_1","first-page":"27","article-title":"Enhanced production of surfactin by Bacillus subtilis E8 mutant obtained by ion beam implantation","volume":"47","author":"Gong G.","year":"2009","journal-title":"Food Technol. 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