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Here, poly(vinylalcohol)\u2010based membranes are developed to be used for mesenchymal stem cell implantation in cartilage repair procedures, having controllable physicochemical properties such as porosity, mechanical strength, and permeability, and a unique self\u2010sealing property. The membranes possess a bilayer structure with a less porous layer providing mechanical strength and selective permeability, exhibit an elastic modulus of between 0.3 and 0.9\u2009MPa, and are permeable to molecules &lt;40\u2009kDa, which is in the range of cartilage permeability. Three different peptide ligands with the sequences Ac\u2010GCGYGRGDSPG, Ac\u2010GCG(OPG)4REGOFG(OPG)4, and Ac\u2010GCG(OPG)7, respectively, are conjugated to the membranes and subject to in vitro cell adhesion and differentiation assays. Col I\/Col II gene expression ratios indicated that the collagen\u2010mimetic peptide, Ac\u2010GCG(OPG)7, best supported mesenchymal stem cell differentiation into the chondrogenic lineage. Although low retention of the membrane is observed in vivo in a rabbit knee model, results suggest that the membrane was able to facilitate mesenchymal stem cell implantation and differentiation to chondrocytes. These PVA\u2010based membranes provide a feasible, synthetic, off\u2010the\u2010shelf material for the delivery of stem cells, and can be modified for other surgical applications.<\/jats:p><\/jats:sec>","DOI":"10.1002\/biot.201700134","type":"journal-article","created":{"date-parts":[[2017,9,11]],"date-time":"2017-09-11T11:28:28Z","timestamp":1505129308000},"source":"Crossref","is-referenced-by-count":7,"title":["Synthetic Poly(Vinylalcohol)\u2010Based Membranes for Cartilage Surgery and Repair"],"prefix":"10.1002","volume":"12","author":[{"given":"Benjamin C. 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