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However, it now faces a serious challenge regarding environmental pollutions and greenhouse gas emission. With the rapid development of molecular biology, biochemistry, and synthetic biology, industrial biotechnology has evolved to become more efficient for production of chemicals and materials. However, in contrast to chemical industries, current industrial biotechnology (CIB) is still not competitive for production of chemicals, materials, and biofuels due to their low efficiency and complicated sterilization processes as well as high\u2010energy consumption. It must be further developed into \u201cnext\u2010generation industrial biotechnology\u201d (NGIB), which is low\u2010cost mixed substrates based on less freshwater consumption, energy\u2010saving, and long\u2010lasting open continuous intelligent processing, overcoming the shortcomings of CIB and transforming the CIB into competitive processes. Contamination\u2010resistant microorganism as chassis is the key to a successful NGIB, which requires resistance to microbial or phage contaminations, and available tools and methods for metabolic or synthetic biology engineering. This review proposes a list of contamination\u2010resistant bacteria and takes\n                    <jats:italic>Halomonas<\/jats:italic>\n                    spp. as an example for the production of a variety of products, including polyhydroxyalkanoates under open\u2010 and continuous\u2010processing conditions proposed for NGIB.\n                  <\/jats:p>","DOI":"10.1002\/biot.201800437","type":"journal-article","created":{"date-parts":[[2019,3,30]],"date-time":"2019-03-30T11:22:12Z","timestamp":1553944932000},"source":"Crossref","is-referenced-by-count":112,"title":["Next\u2010Generation Industrial Biotechnology\u2010Transforming the Current Industrial Biotechnology into Competitive Processes"],"prefix":"10.1002","volume":"14","author":[{"given":"Lin\u2010Ping","family":"Yu","sequence":"first","affiliation":[{"name":"Ministry of Education\u00a0Key Laboratory\u00a0for\u00a0Bioinformatics, School of Life Sciences Tsinghua University  New Biology Building 100084 Beijing China"},{"name":"Center for Synthetic and Systems Biology Tsinghua University  New Biology Building 100084 Beijing China"},{"name":"Tsinghua\u2010Peking Center for Life Sciences Tsinghua University  New Biology Building 100084 Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu\u2010Qing","family":"Wu","sequence":"additional","affiliation":[{"name":"Ministry of Education\u00a0Key Laboratory\u00a0for\u00a0Bioinformatics, School of Life Sciences Tsinghua University  New Biology Building 100084 Beijing China"},{"name":"Center for Synthetic and Systems Biology Tsinghua University  New Biology Building 100084 Beijing China"},{"name":"Tsinghua\u2010Peking Center for Life Sciences Tsinghua University  New Biology Building 100084 Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo\u2010Qiang","family":"Chen","sequence":"additional","affiliation":[{"name":"Ministry of Education\u00a0Key Laboratory\u00a0for\u00a0Bioinformatics, School of Life Sciences Tsinghua University  New Biology Building 100084 Beijing China"},{"name":"Center for Synthetic and Systems Biology Tsinghua University  New Biology Building 100084 Beijing China"},{"name":"Tsinghua\u2010Peking Center for Life Sciences Tsinghua University  New Biology Building 100084 Beijing China"},{"name":"Manchester Institute of Biotechnology, Centre for Synthetic Biology The University of Manchester  131 Princess Street Manchester M1 7DN UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,28]]},"reference":[{"key":"e_1_2_10_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2005.03.004"},{"key":"e_1_2_10_1_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.7b04573"},{"key":"e_1_2_10_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/bit.21875"},{"key":"e_1_2_10_1_5_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2016.0087"},{"key":"e_1_2_10_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2013.05.011"},{"key":"e_1_2_10_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/bit.22592"},{"key":"e_1_2_10_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apenergy.2010.12.050"},{"key":"e_1_2_10_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2017.11.016"},{"key":"e_1_2_10_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2012.12.007"},{"key":"e_1_2_10_1_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2859-11-111"},{"key":"e_1_2_10_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2014.06.001"},{"key":"e_1_2_10_1_13_1","first-page":"131","volume":"2010","author":"Willke T.","year":"2010","journal-title":"Appl. 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