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Packed\u2010bed or fixed\u2010bed reactors, where column is packed with immobilized biocatalyst particles providing surface to constrain the cells in a particular region of the reactor, have been widely used in bioprocessing applications since mid\u20101900s. However, the world's first single\u2010use, fully integrated, high cell density, fixed\u2010bed bioreactor was launched only approximately a decade ago. By now, several single\u2010use, fixed\u2010bed technology solutions have been developed in a small scale. Scaling\u2010up the manufacturing can be challenging and for commercial\u2010scale manufacturing, there is practically only one single\u2010use, good manufacturing practice\u2010compliant option available. This study reviews the latest, fully disposable, fixed\u2010bed bioreactors; compares the virus production in the different systems; and discusses important manufacturing cost\u2010related topics. 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