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Various cell\u2010therapies have been recently developed via the exogenous administration of mesenchymal stem cells (MSCs) due to their intrinsic regenerative capacity of self\u2010renewal and chondrogenic differentiation. However, MSC\u2010based cellular approaches have exhibited some technical limitations including dedifferentiation during MSC expansion, reduction of regenerative efficacy upon administration, and inconsistent quality control in large\u2010scale cell production. To overcome these disadvantages, exosome mediated cartilage tissue regeneration has been investigated. Since exosome derived from MSC (MSC\u2010exosome) transport and deliver multiple cellular components from their original MSC sources, they could be utilized as alternative therapeutic agents for OA treatment. Recent studies have shown that the administration of MSC\u2010exosome effectively reduced a production of inflammatory cytokines in chondrocytes, increased the expression of cartilage ECM component, and eventually augment cartilage tissue regeneration in a series of in vivo studies. Therefore, this review emphasizes current engineering approaches via MSC\u2010exosome for cartilage tissue repair, as a functional OA treatment technique.<\/jats:p>","DOI":"10.1002\/biot.202000082","type":"journal-article","created":{"date-parts":[[2020,6,19]],"date-time":"2020-06-19T12:09:35Z","timestamp":1592568575000},"source":"Crossref","is-referenced-by-count":159,"title":["Mesenchymal Stem Cell\u2010Derived Exosomes for Effective Cartilage Tissue Repair and Treatment of Osteoarthritis"],"prefix":"10.1002","volume":"15","author":[{"given":"Young Guk","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Chemical and Biochemical Engineering Dongguk University  30 Pildong\u2010ro 1\u2010gil Seoul 04620 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonghoon","family":"Choi","sequence":"additional","affiliation":[{"name":"School of Integrative Engineering Chung\u2010Ang University  47 Heukseok\u2010ro Seoul 06911 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyobum","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biochemical Engineering Dongguk University  30 Pildong\u2010ro 1\u2010gil Seoul 04620 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,13]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.csm.2017.02.001"},{"key":"e_1_2_10_2_1","first-page":"477","volume":"21","author":"Wachsmuth L.","year":"2006","journal-title":"Histol. 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