{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T04:07:17Z","timestamp":1791518837364,"version":"4.3.4"},"reference-count":162,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T00:00:00Z","timestamp":1599091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21727816"],"award-info":[{"award-number":["21727816"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31925025"],"award-info":[{"award-number":["31925025"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91859108"],"award-info":[{"award-number":["91859108"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biotechnology Journal"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Vaccination is successfully advanced to control several fatal diseases and improve human life expectancy. However, additional innovations are required in this field because there are no effective vaccines to prevent some infectious diseases. The shift from the attenuated or inactivated pathogens to safer but less immunogenic protein or peptide antigens has led to a search for effective antigen delivery carriers that can function as both antigen vehicles and intrinsic adjuvants. Among these carriers, self\u2010assembled nanoparticles (SANPs) have shown great potential to be the best representative. For the nanoscale and multiple presentation of antigens, with accurate control over size, geometry, and functionality, these nanoparticles are assembled spontaneously and mimic pathogens, resulting in enhanced antigen presentation and increased cellular and humoral immunity responses. In addition, they may be applied through needle\u2010free routes due to their adhesive ability, which gives them a great future in vaccination applications. This review provides an overview of various SANPs and their applications in prophylactic vaccines.<\/jats:p>","DOI":"10.1002\/biot.202000087","type":"journal-article","created":{"date-parts":[[2020,7,28]],"date-time":"2020-07-28T19:51:50Z","timestamp":1595965910000},"source":"Crossref","is-referenced-by-count":34,"title":["Self\u2010Assembled Nanoparticles: Exciting Platforms for Vaccination"],"prefix":"10.1002","volume":"15","author":[{"given":"Jingdi","family":"Pan","sequence":"first","affiliation":[{"name":"State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega\u2010Science Chinese Academy of Sciences  Wuhan 430071 China"},{"name":"University of Chinese Academy of Sciences  Beijing 100049 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1118-8489","authenticated-orcid":false,"given":"Zongqiang","family":"Cui","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega\u2010Science Chinese Academy of Sciences  Wuhan 430071 China"},{"name":"University of Chinese Academy of Sciences  Beijing 100049 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,3]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1402981111"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(03)00377-3"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2668"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200464180-00003"},{"key":"e_1_2_9_5_1","first-page":"3","volume-title":"Textbook of Influenza","author":"Jernigan D. B.","year":"2013"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781118636817.ch2"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11262-010-0547-7"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/289189a0"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/d41586-020-00751-9"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.28120"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1051\/jbio\/2012027"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1070821"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.csbj.2015.11.001"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2010.09.077"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2017.03.033"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2017.05.013"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00022"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201800670"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12038-009-0114-3"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1586\/14760584.1.3.265"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbi.2004.06.006"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2017.05.002"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9CP01088B"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201801223"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2868"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2007.01.111"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1586\/erv.10.89"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2017.03.005"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiolchem.2019.03.003"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1219364"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.2107"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.6b00521"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201700137"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/marc.201600528"},{"key":"e_1_2_9_35_1","first-page":"1459394","volume":"2016","author":"Jde A.","year":"2016","journal-title":"J. Immunol. Res."},{"key":"e_1_2_9_36_1","first-page":"360","volume":"22","author":"Yousefi S.","year":"2019","journal-title":"Iran. J. Basic Med. Sci."},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.70.6.849"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2005.07.005"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e31819d6394"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1586\/14760584.6.5.699"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2006.01.015"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2018.1515454"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1586\/erv.12.140"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2011.01.011"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1586\/erv.10.141"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.2165\/00063030-200822050-00001"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.5752"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408390591001135"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570161043385736"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.2174\/156720105774370230"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425247.2011.558081"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425247.2010.488687"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2010.50"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b17399"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.2000.01447.x"},{"key":"e_1_2_9_56_1","first-page":"2327","volume":"2","author":"Sharma R.","year":"2010","journal-title":"Int. J. PharmTech Res."},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.2174\/156720105774370302"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2004.09.002"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2009.05.029"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(02)00545-5"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2008.59"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.4155\/ppa.15.38"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2003.12.031"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2015.06.047"},{"key":"e_1_2_9_65_1","first-page":"39685","volume":"22","author":"Malliarosa J.","year":"2004","journal-title":"Vaccine"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2018.04.041"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aao1736"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612822666161021104239"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2cs15344k"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1039\/B914943K"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753425910374889"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2011.02.004"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2015.05.010"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2012.03.017"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.5812\/jjm.27035"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00934"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.24253"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2018.02.072"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2012.01.054"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2007.12.014"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0080904"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2010.10.008"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S185806"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000328"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2016.03.002"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0962-8924(00)01898-5"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02725-4"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1805713115"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-019-0390-x"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2019.02.004"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-11-78"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01050-17"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.03159-15"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2018.11.009"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1115485109"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep19234"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2016.03.002"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2009.12.005"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1080\/17425247.2017.1243528"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1978.58.2.317"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2728(96)00022-9"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1021\/bm200026v"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1996.0007"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201703207"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12202"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3927"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aan2676"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02810-18"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-018-0305-x"},{"key":"e_1_2_9_110_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.7b00192"},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2018.05.034"},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xphs.2018.05.002"},{"key":"e_1_2_9_113_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-7893-9_4"},{"key":"e_1_2_9_114_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.12255"},{"key":"e_1_2_9_115_1","doi-asserted-by":"publisher","DOI":"10.1248\/yakushi.18-00169-2"},{"key":"e_1_2_9_116_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8CS00154E"},{"key":"e_1_2_9_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.11.072"},{"key":"e_1_2_9_118_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1234150"},{"key":"e_1_2_9_119_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-92165-3_14"},{"key":"e_1_2_9_120_1","doi-asserted-by":"publisher","DOI":"10.1080\/14760584.2016.1175942"},{"key":"e_1_2_9_121_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics11050211"},{"key":"e_1_2_9_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2012.01.005"},{"key":"e_1_2_9_123_1","doi-asserted-by":"publisher","DOI":"10.1586\/erv.09.163"},{"key":"e_1_2_9_124_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.13.6154-6165.2001"},{"key":"e_1_2_9_125_1","doi-asserted-by":"publisher","DOI":"10.1080\/08820139.2018.1544640"},{"key":"e_1_2_9_126_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001501"},{"key":"e_1_2_9_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2008.07.084"},{"key":"e_1_2_9_128_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1313186"},{"key":"e_1_2_9_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2019.03.018"},{"key":"e_1_2_9_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2013.02.009"},{"key":"e_1_2_9_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.10.083"},{"key":"e_1_2_9_132_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-7652.2008.00384.x"},{"key":"e_1_2_9_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2016.03.008"},{"key":"e_1_2_9_134_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn4006544"},{"key":"e_1_2_9_135_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0045765"},{"key":"e_1_2_9_136_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009809"},{"key":"e_1_2_9_137_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01694-12"},{"key":"e_1_2_9_138_1","doi-asserted-by":"publisher","DOI":"10.3390\/v12010035"},{"key":"e_1_2_9_139_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/126794"},{"key":"e_1_2_9_140_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf8818"},{"key":"e_1_2_9_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.01.046"},{"key":"e_1_2_9_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.02.008"},{"key":"e_1_2_9_143_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-12080-1"},{"key":"e_1_2_9_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-409X(01)00149-1"},{"key":"e_1_2_9_145_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1213"},{"key":"e_1_2_9_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2008.09.005"},{"key":"e_1_2_9_147_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425247.3.4.463"},{"key":"e_1_2_9_148_1","first-page":"331","volume":"16","author":"Prego C.","year":"2006","journal-title":"J. Controlled Release"},{"key":"e_1_2_9_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2006.03.017"},{"key":"e_1_2_9_150_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.28339"},{"key":"e_1_2_9_151_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-08265-9"},{"key":"e_1_2_9_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2015.10.025"},{"key":"e_1_2_9_153_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-051116-052215"},{"key":"e_1_2_9_154_1","doi-asserted-by":"publisher","DOI":"10.1385\/IR:36:1:127"},{"key":"e_1_2_9_155_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1600893"},{"key":"e_1_2_9_156_1","doi-asserted-by":"publisher","DOI":"10.1586\/14760584.2015.1029919"},{"key":"e_1_2_9_157_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2018.12.049"},{"key":"e_1_2_9_158_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0206837"},{"key":"e_1_2_9_159_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep27217"},{"key":"e_1_2_9_160_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2014.07.095"},{"key":"e_1_2_9_161_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2018.04.039"},{"key":"e_1_2_9_162_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb1005"}],"container-title":["Biotechnology Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbiot.202000087","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/biot.202000087","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/biot.202000087","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/biot.202000087","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T20:36:46Z","timestamp":1759955806000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/biot.202000087"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,3]]},"references-count":162,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1002\/biot.202000087"],"URL":"https:\/\/doi.org\/10.1002\/biot.202000087","archive":["Portico"],"relation":{},"ISSN":["1860-6768","1860-7314"],"issn-type":[{"value":"1860-6768","type":"print"},{"value":"1860-7314","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,3]]},"article-number":"2000087"}}