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These models expand opportunities for high throughput screening (HTS) of drugs and are likely to be rapid and cost\u2010effective, thus reducing extensive usage of animal models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Through\u00a0this review article, we aim to present an overview of the degenerative disease models that are presently being developed using microfluidic platforms with the aim of mimicking in vivo tissue physiology and micro\u2010architecture. The manuscript provides an overview of the degenerative disease models and their potential for testing and screening of possible biotherapeutic molecules and drugs. 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