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The nanocomposite enhances the drug activity of immobilized 5\u2010fluorouracil (5\u2010FU), decreasing the side effect of long\u2010run treatment protocols with highly efficient drug\u2010drug activity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method and results<\/jats:title><jats:p>Different samples were characterized by ATR\u2010FTIR spectroscopy, X\u2010ray diffraction, scanning electron microscopy coupled with energy dispersive X\u2010ray analysis, transmission electron microscopy, thermogravimetric analysis, and dynamic light scattering along with cytotoxicity and anticancer study. A homogenous and compatible nanocomposite structure with a homogenous drug distribution was confirmed. Furthermore, the prepared nanocomposite has a low cytotoxicity effect against normal Vero cell lines compared with 5\u2010FU. The antitumor activities of the same nanocomposite (20.4 and 74.3\u00a0\u03bcg mL<jats:sup>\u22121<\/jats:sup> on A549 and HepG\u20102) were lower than that of 5\u2010FU (54.1 and 103\u00a0\u03bcg mL<jats:sup>\u22121<\/jats:sup> on A549 and HepG\u20102).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion and implications<\/jats:title><jats:p>According to the attained results, the HPMC\/5\u2010FL@GO can apply in a biomedical application such as cancer therapy with the unique biocompatible to human cells.<\/jats:p><\/jats:sec>","DOI":"10.1002\/biot.202100183","type":"journal-article","created":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T15:56:16Z","timestamp":1631202976000},"source":"Crossref","is-referenced-by-count":37,"title":["Hydroxypropyl methylcellulose\/graphene oxide composite as drug carrier system for 5\u2010fluorouracil"],"prefix":"10.1002","volume":"17","author":[{"given":"Mohamed S.","family":"Hasanin","sequence":"first","affiliation":[{"name":"Cellulose and Paper Department National Research Centre  Dokki Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"El\u2010Sakhawy","sequence":"additional","affiliation":[{"name":"Cellulose and Paper Department National Research Centre  Dokki Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanaa. 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