{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:45:25Z","timestamp":1777941925764,"version":"3.51.4"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,12,26]],"date-time":"2021-12-26T00:00:00Z","timestamp":1640476800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biotechnology Journal"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Neonatal hypoxic\u2010ischemic encephalopathy arises from a reduction of oxygen and blood supply to the infant brain and can lead to severe brain damage and life\u2010long disability. The damage is greatest at the irreversibly injured necrotic core, whereas the penumbra is the surrounding, potentially salvageable tissue populated with a mix of alive and dying cells. To date, there exists no method for targeting drugs to the brain damage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Major Results<\/jats:title><jats:p>Bacteriophages are viruses that propagate in bacteria but are biocompatible in humans and also amenable to genetic and chemical modification in a manner distinctive from conventional therapeutic nanoparticles. Here, a library of M13 bacteriophage was administered into a rat model of hypoxic\u2010ischemic encephalopathy, and unique bacteriophage clones were confirmed to localize in healthy brain tissue versus the core and penumbra zones of injury.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>For the first time, there is a potential to directly deliver therapeutics to different regions of the neonatal brain injury.<\/jats:p><\/jats:sec>","DOI":"10.1002\/biot.202100226","type":"journal-article","created":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T06:59:01Z","timestamp":1639033141000},"source":"Crossref","is-referenced-by-count":1,"title":["Bacteriophage carriers localize in the brain of a rat model of neonatal hypoxic\u2010ischemic encephalopathy"],"prefix":"10.1002","volume":"17","author":[{"given":"Abdullah K.","family":"Alshememry","sequence":"first","affiliation":[{"name":"Nanobiotechnology Unit Department of Pharmaceutics College of Pharmacy King Saud University  Riyadh Saudi Arabia"},{"name":"Department of Pharmaceutics College of Pharmacy King Saud University  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung\u2010Lynn Jonathan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Chemical and Materials Engineering University of Alberta  Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward A.","family":"Armstrong","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Alberta  Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerome Y.","family":"Yager","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Alberta  Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3162-3545","authenticated-orcid":false,"given":"Larry 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