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The aim of this study was to optimize the extraction of onions, the preparation of sodium alginate\/collagen\/hydrogen boron nitride (NaAlg\/Col\/h\u2010BN) membranes using the Box\u2010Behnken experimental design, and determine the optimal conditions for quercetin release. The study also aimed to investigate the antimicrobial and antioxidant activities of the prepared membranes and their therapeutic properties.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>The prepared membranes were characterized by scanning electron microscopy (SEM), fourier transform infrared (FTIR), differential scanning calorimetry (DSC), and X\u2010ray diffraction (XRD). Antimicrobial activities were tested against Gram\u2010negative (Gr\u2010) <jats:italic>Escherichia coli<\/jats:italic> ATCC 25922, <jats:italic>Klebsiella pneumonia<\/jats:italic>, <jats:italic>Enterobacter aerogenes<\/jats:italic>, Gram\u2010positive (Gr+) <jats:italic>Staphylococcus aureus<\/jats:italic> ATCC 25923, and <jats:italic>Candida albicans<\/jats:italic> ATCC 10231 pathogens. In vitro release studies were conducted to examine the therapeutic properties of the prepared membranes. The optimum conditions for the extraction of onions and the preparation of NaAlg\/Col\/h\u2010BN membranes were found to be EtOH\u00a0=\u00a075\u00a0mL, <jats:italic>t<\/jats:italic>\u00a0=\u00a02\u00a0h, <jats:italic>T<\/jats:italic>\u00a0=\u00a045\u00b0C, and NaAlg\u00a0=\u00a01.0\u00a0g, Col\u00a0=\u00a02.0\u00a0g, and h\u2010BN\u00a0=\u00a06%\u00a0wt, respectively. The prepared membranes exhibited serious antimicrobial properties against <jats:italic>S. aureus<\/jats:italic> and <jats:italic>C. albicans<\/jats:italic>. The membranes also promoted the controlled release of quercetin for 24\u00a0h in vitro, indicating their potential as a new approach in wound treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The study concludes that quercetin\u2010filled NaAlg\/Col\/h\u2010BN membranes have promising therapeutic properties for wound healing. The membranes exhibited significant antimicrobial and antioxidant properties, and their controlled release of quercetin suggests their potential for use in wound healing applications.<\/jats:p><\/jats:sec>","DOI":"10.1002\/biot.202300147","type":"journal-article","created":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T01:28:20Z","timestamp":1698456500000},"source":"Crossref","is-referenced-by-count":5,"title":["Quercetin\u2010loaded sodium alginate\/collagen\/h\u2010boron nitride potential wound dressings prepared using the Box\u2010Behnken experimental design"],"prefix":"10.1002","volume":"19","author":[{"given":"G\u00fcl\u015fen Ta\u015fk\u0131n","family":"\u00c7ak\u0131c\u0131","sequence":"first","affiliation":[{"name":"Department of Chemistry and Chemical Processing Technologies Vocational School of Technical Sciences Gazi University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Se\u00e7il","family":"Kaya","sequence":"additional","affiliation":[{"name":"Department of Material and Material Processing Technologies Vocational School of Technical Sciences Gazi University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sema Yiyit","family":"Do\u011fan","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Processing Technologies Vocational School of Technical Sciences Gazi University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6260-9247","authenticated-orcid":false,"given":"Ebru Kondolot","family":"Solak","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Processing Technologies Vocational School of Technical Sciences Gazi University  Ankara Turkey"},{"name":"Department of Advanced Technologies Gazi University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2014.09.036"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ifset.2008.07.002"},{"key":"e_1_2_8_4_1","first-page":"140","article-title":"In\u2010vitro antioxidant activity of methanolic extraction of Ficus Benghalensis L. latex","volume":"1","author":"Yadav Y. 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