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Several newly designed carrier systems for Am\u2010B can also be considered orally with sufficient gastrointestinal permeability and good solubility. However, the clinical application of several new formulations of Am\u2010B with organ cytotoxicity, low bioavailability, high costs, and technical problems have caused some issues. Therefore, more attention and scientific design are required to progress safe and effective drug delivery systems. Currently, the application of nano\u2010based technology and nanomaterials in the advancement of drug delivery systems exhibits promising outcomes to cure many human systemic infections. Designing novel drug delivery systems including solid lipid nanostructured materials, lipo\u2010polymersomes, drug conjugates and microneedles, liposomes, polymer and protein\u2010based nanostructured materials, dendrimers, emulsions, mixed micelles, polymeric micelles, cyclodextrins, nanocapsules, and nanocochleate for Am\u2010B has many advantages to reducing several related issues. The unique properties of nanostructured particles such as proper morphology, small size, surface coatings, and, electrical charge, permit scientists to design new nanocomposite materials against microorganisms for application in various human diseases. These features have made these nanoparticles an ideal candidate for drug delivery systems in clinical approaches to cure a number of human disorders and currently, several therapeutic nanostructured material formulations are under different stages of clinical tests. Hence, this scientific paper mainly discussed the advances in new formulations of Am\u2010B for the treatment of human systemic infections and related clinical tests.<\/jats:p>","DOI":"10.1002\/biot.202300462","type":"journal-article","created":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T00:58:16Z","timestamp":1702256296000},"source":"Crossref","is-referenced-by-count":9,"title":["Developing nanosize carrier systems for Amphotericin\u2010B: A review on the biomedical application of nanoparticles for the treatment of leishmaniasis and fungal infections"],"prefix":"10.1002","volume":"19","author":[{"given":"Neda","family":"Sharifi","sequence":"first","affiliation":[{"name":"Department of Cell and Molecular Biology and Microbiology Faculty of Biological Science and Technology University of Isfahan  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Alitaneh","sequence":"additional","affiliation":[{"name":"Quantitative and System Biology Department of Natural Sciences University of California Merced, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahar","family":"Asadi","sequence":"additional","affiliation":[{"name":"Department of Community and Family Medicine School of Medicine Ardabil University of Medical Sciences  Ardabil Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeinab","family":"Vahidinia","sequence":"additional","affiliation":[{"name":"Anatomical Sciences Research Center Institute for Basic Sciences Kashan University of Medical Sciences  Kashan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Mohsen","family":"Aghaei Zarch","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics School of Medicine Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Esmaeili","sequence":"additional","affiliation":[{"name":"Department of Tissue Engineering and Applied Cell Sciences School of Advanced Technologies in Medicine Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6771-4185","authenticated-orcid":false,"given":"Saeid","family":"Bagheri\u2010Mohammadi","sequence":"additional","affiliation":[{"name":"Department of Physiology School of Medicine Mazandaran University of Medical Sciences  Sari Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7226-5778","authenticated-orcid":false,"given":"Sajad","family":"Najafi","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnology School of Advanced Technologies in Medicine Shahid Beheshti University of Medical Sciences  Tehran Iran"},{"name":"Cellular and Molecular Biology Research Center Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosra","family":"Mazhari","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Infectious Diseases Research Center School of Medicine Iran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,15]]},"reference":[{"key":"e_1_2_21_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12585"},{"issue":"35","key":"e_1_2_21_3_1","first-page":"401","article-title":"Global leishmaniasis surveillance: 2019\u20132020, a baseline for the 2030 roadmap\/Surveillance mondiale de la leishmaniose: 2019\u20132020, une periode de reference pour la feuille de route a l'horizon 2030","volume":"96","author":"Ruiz\u2010Postigo J. 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