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Vaccine development often confronts big challenges, including time\/energy\u2010consuming, low efficacy, lag to pathogen emergence and mutation, and even safety concern. However, these seem now mostly conquerable through constructing the advanced translational platforms that can make innovative vaccines, sometimes, potentiated with a distinct multifunctional VADS (vaccine adjuvant delivery system), as evidenced by the development of various vaccines against the covid\u201019 pandemic at warp speed. Particularly, several covid\u201019 vaccines, such as the viral\u2010vectored vaccines, mRNA vaccines and DNA vaccines, regarded as the innovative ones that are rapidly made via the high technology\u2010based translational platforms. These products have manifested powerful efficacy while showing no unacceptable safety profile in clinics, allowing them to be approved for massive vaccination at also warp speed. Now, the proprietary translational platforms integrated with the state\u2010of\u2010the\u2010art biotechnologies, and even the artificial intelligence (AI), represent an efficient mode for rapid making innovative clinical vaccines against infections, thus increasingly attracting interests of vaccine research and development. Herein, the advanced translational platforms for making innovative vaccines, together with their design principles and immunostimulatory efficacies, are comprehensively elaborated.<\/jats:p>","DOI":"10.1002\/biot.202300658","type":"journal-article","created":{"date-parts":[[2024,2,25]],"date-time":"2024-02-25T21:10:15Z","timestamp":1708895415000},"source":"Crossref","is-referenced-by-count":7,"title":["Innovative translational platforms for rapid developing clinical vaccines against COVID\u201019 and other infectious disease"],"prefix":"10.1002","volume":"19","author":[{"given":"Ning","family":"Wang","sequence":"first","affiliation":[{"name":"School of Food and Biological engineering Hefei University of Technology  Hefei Anhui Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4654-5869","authenticated-orcid":false,"given":"Ting","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy Anhui Medical 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