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Many investigations have been conducted recently to modify their pore dimensions, expansion, biodegradability, stimulus\u2010reaction characteristics, and other characteristics in order to better tailor them to the complex craniofacial tissues. They have\u00a0been the focus of various studies that have attempted to load biological cargos for therapeutic and regenerative uses in the oro\u2010facial tissues. This article assesses the utility and advancements of chitosan thermosensitive hydrogel\u2010based pharmaceutical delivery devices for the management of craniofacial disorders such as dental caries, endodontic diseases, periodontitis, temporomandibular disorders, mucosal diseases, cancer, and so forth.<\/jats:p>","DOI":"10.1002\/biot.202400653","type":"journal-article","created":{"date-parts":[[2025,1,25]],"date-time":"2025-01-25T03:06:59Z","timestamp":1737774419000},"source":"Crossref","is-referenced-by-count":18,"title":["Bioactive Functionalized Chitosan Thermo\u2010Responsive Hydrogels as Promising Platforms for Therapeutic, Regenerative Oral, and Maxillofacial Applications"],"prefix":"10.1002","volume":"20","author":[{"given":"Meshari","family":"Alkandari","sequence":"first","affiliation":[{"name":"Department of Dentistry Rumaithiya Polyclinic Ministry of Health  Rumaithiya Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paritosh","family":"Barai","sequence":"additional","affiliation":[{"name":"Department of Marine Biotechnology &amp; 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