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Stem cells with their self\u2010renewal capacity, lineage\u2010specific differentiation, and intrinsic tumor\u2010homing ability have attracted considerable attention as potential mediators of targeted cancer therapy. Concurrently, nanotechnology offers tunable physicochemical properties and advanced tissue penetration, providing versatile platforms for drug delivery, imaging, and diagnostics. The convergence of nanotechnology and stem cell biology has expanded the therapeutic landscape, enabling multifunctional strategies for targeted drug delivery, imaging, and diagnostics. This review examines the challenges of drug delivery in oncology, elucidates the biological rationale for stem cell\u2013mediated therapies, and explores the role of nanotechnology in augmenting their potential, emphasizing how the tumor\u2010homing capacity of stem cells can be exploited to overcome major barriers in conventional therapies. 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