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We engineered human umbilical cord mesenchymal stem cell\u2010derived extracellular vesicles (hUC\u2010MSC\u2010EVs) to deliver emodin\u2014a bioactive compound limited by poor bioavailability\u2014for targeted intestinal protection. In TNF\u2010\u03b1\u2010stimulated intestinal epithelial cells (CCD\u2010841CON), EV\u2010loaded emodin (EVs\u2010Emodin) synergistically suppressed NLRP3 inflammasome activation, pyroptosis, reactive oxygen species production, and inflammatory cytokines, outperforming monotherapies. EVs\u2010Emodin restored cell viability and curtailed apoptosis. In taurocholate\u2010induced AP mice, intravenous EVs\u2010Emodin attenuated systemic inflammation, promoted the expression of Occludin and ZO\u20101, mitigated intestinal tissue lesions, promoted epithelial regeneration, inhibited inflammasome activation, and alleviated mitochondrial damage. hUC\u2010MSC\u2010EVs overcome emodin's delivery limitations, providing a synergistic strategy to protect the intestinal barrier via NLRP3\/pyroptosis inhibition and oxidative stress mitigation, offering a promising therapeutic approach for AP\u2010associated intestinal injury.<\/jats:p>","DOI":"10.1002\/biot.70198","type":"journal-article","created":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T06:47:06Z","timestamp":1771224426000},"source":"Crossref","is-referenced-by-count":0,"title":["Human Umbilical Cord Mesenchymal Stem Cell\u2010Derived Extracellular Vesicles Loaded with Emodin Alleviate Intestinal Injury in Acute 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