{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T22:42:37Z","timestamp":1789166557092,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82203056"],"award-info":[{"award-number":["82203056"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biotechnology Journal"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Small cell lung cancer (SCLC) is a highly aggressive malignancy, and chemotherapy frequently causes nausea and vomiting, which can impair treatment tolerance. Because thalidomide (THD) has shown potential clinical benefit in alleviating nausea and anorexia, we investigated whether its effects might be associated with changes in gut microbial composition and metabolite profiles. Fecal samples were collected from patients with SCLC and categorized into THD\u2010treated and control groups. Metagenomic sequencing and nontargeted metabolomic profiling were performed to characterize microbial composition and metabolic signatures. THD treatment was also associated with higher microbial alpha diversity and increased abundance of genera such as\n                    <jats:italic>Eubacterium<\/jats:italic>\n                    and\n                    <jats:italic>Prevotella<\/jats:italic>\n                    . Metabolomic analysis identified several differential metabolites, including hydrogenated MDI, becocalcidiol, \u03b2\u2010octylglucoside, and azelaic acid. Collectively, these findings suggest that the gut microbiota\u2010metabolite axis may be associated with the potential effects of THD on CINV and anorexia in patients with SCLC. The identified microbial taxa and metabolites may serve as candidate biomarkers or potential therapeutic targets, although further validation in larger studies is necessary.\n                  <\/jats:p>","DOI":"10.1002\/biot.70228","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T10:51:30Z","timestamp":1776423090000},"source":"Crossref","is-referenced-by-count":1,"title":["Multi\u2010omics Analysis Reveals the Correlation of Gut Microbiota and Metabolites With Thalidomide Treatment for Chemotherapy\u2010Induced Nausea and Vomiting in Small Cell Lung Cancer"],"prefix":"10.1002","volume":"21","author":[{"given":"Qiang\u2010Guo","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Oncology The Second Hospital of Dalian Medical University  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Zang","sequence":"additional","affiliation":[{"name":"Department of Oncology The Second Hospital of 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