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Clinical outcomes, including weekly bowel movement frequency, Bristol stool scale scores, and Wexner constipation scores, were assessed. Serum 5\u2010hydroxytryptamine (5\u2010HT) levels and fecal microbiota profiles were analyzed to evaluate neurogastrointestinal and microbial responses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>L. plantarum<\/jats:italic>\n                      Z6 supplementation significantly increased weekly bowel movements and Bristol stool scores while reducing Wexner scores (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05). Serum 5\u2010HT concentrations were elevated, indicating improved gastrointestinal motility. Gut microbiota analysis revealed enhanced \u03b1\u2010diversity, higher abundances of\n                      <jats:italic>Bifidobacterium<\/jats:italic>\n                      ,\n                      <jats:italic>Gemmiger<\/jats:italic>\n                      , and\n                      <jats:italic>Lactobacillus<\/jats:italic>\n                      , and reduced\n                      <jats:italic>Streptococcus<\/jats:italic>\n                      . Correlation analysis demonstrated a positive association between\n                      <jats:italic>L. plantarum<\/jats:italic>\n                      Z6 intake and\n                      <jats:italic>Bifidobacterium<\/jats:italic>\n                      enrichment, suggesting targeted modulation of beneficial taxa.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      <jats:italic>L. plantarum<\/jats:italic>\n                      Z6 is a safe and effective probiotic intervention for infantile functional constipation. The results highlight its potential to improve bowel function and beneficially reshape the gut microbiota, offering a microbiota\u2010targeted therapeutic strategy for pediatric gastrointestinal disorders.\n                    <\/jats:p>\n                    <jats:p>\n                      <jats:bold>Chinese Clinical Trial Registry ID<\/jats:bold>\n                      : ChiCTR2300073079\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/biot.70233","type":"journal-article","created":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T05:26:22Z","timestamp":1777699582000},"source":"Crossref","is-referenced-by-count":0,"title":["<i>Lactiplantibacillus plantarum<\/i>\n                    Z6 Improves Functional Constipation in Infants"],"prefix":"10.1002","volume":"21","author":[{"given":"Xiaoni","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology the Second People's Hospital of Jingdezhen  Jingdezhen Jiangxi 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