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Emerging bioengineering technologies, including tissue engineering, microfluidic chips, imaging techniques, personalized medicine, gene editing tools, and artificial intelligence, have the potential to revolutionize the existing assisted reproductive technology. These technologies have enabled creating artificial biomimetic systems for the culture of oocytes and embryos; changed the way they develop; and enhanced their competence evaluation in an automatic manner. However, the implementation and potential integration of these technologies have been a long\u2010entrenched challenge due to the lack of standardized protocols and precise control over reproductive cycles. This review article summarizes recent advances in these innovative approaches, with an emphasis on tissue engineering and microfluidic technology. Their convergence is discussed as a potential pathway toward more integrated, precise, and personalized reproductive systems for next\u2010generation assisted reproductive technology. In this context, key challenges related to ethics, standardization, cross\u2010technology integration, and clinical translation are further discussed.<\/jats:p>","DOI":"10.1002\/biot.70274","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T11:21:23Z","timestamp":1782732083000},"source":"Crossref","is-referenced-by-count":0,"title":["Emerging Bioengineering Technologies in Female Reproduction: Preclinical Advances, Translational Challenges, and Future Outlook"],"prefix":"10.1002","volume":"21","author":[{"given":"Thu Hang","family":"Nguyen","sequence":"first","affiliation":[{"name":"University of Engineering and Technology Vietnam National University  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hung Anh","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering University of California  Irvine USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y\u2010Van Tran","family":"Thi","sequence":"additional","affiliation":[{"name":"National University of Singapore  Queenstown Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoang Trung","family":"Nguyen","sequence":"additional","affiliation":[{"name":"University of Engineering and Technology Vietnam National University  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amber","family":"Cao","sequence":"additional","affiliation":[{"name":"University High School  Irvine USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quang Loc","family":"Do","sequence":"additional","affiliation":[{"name":"University of Engineering and Technology Vietnam National University  Hanoi Vietnam"},{"name":"University of Science Vietnam National University  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thanh Tung","family":"Bui","sequence":"additional","affiliation":[{"name":"University of Engineering and Technology Vietnam National University  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duc Trinh","family":"Chu","sequence":"additional","affiliation":[{"name":"University of Engineering and Technology Vietnam National University  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hung","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering University of California  Irvine USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","unstructured":"The Lancet Global Health.Infertility\u2014Why the Silence?10(6) (2022):773.https:\/\/doi.org\/10.1016\/S2214\u2010109X(22)00215\u20107.","DOI":"10.1016\/S2214-109X(22)00215-7"},{"key":"e_1_2_9_3_1","volume-title":"Physiology, Female Reproduction","author":"Rosner J.","year":"2022"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-9513-7_18"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1017\/9781108788250.018"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu709"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2017.09.008"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.DIFF.2019.07.004"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-19-9410-4_21"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.PLACENTA.2006.11.002"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470390290"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.MAD.2020.111377"},{"key":"e_1_2_9_13_1","volume-title":"Sociality, Hierarchy, Health: Comparative Biodemography: A Collection of Papers","author":"Ellison P. 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