{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:50:45Z","timestamp":1791287445149,"version":"4.1.0"},"reference-count":95,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biotechnology Journal"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Adhesive hydrogels (AHs) are promising biomaterials for cardiac tissue engineering due to their injectability, ability to adhere to wet tissue, and structural similarity to the native extracellular matrix (ECM). This review evaluates the perspectives, opportunities, and challenges associated with AHs in cardiac tissue repair and functional recovery. Adhesion is achieved through chemical mechanisms including Schiff base reactions, Michael addition, and enzymatic crosslinking, as well as physical interactions including hydrogen bonding, host\u2013guest complexation, and catechol\u2010based binding. These mechanisms support integration with the dynamic and mechanically active cardiac surface ensuring the localized and sustained delivery of cells\/therapeutics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Peer reviewed articles were identified through searches of PubMed and Embase using terms related to \u201cadhesive hydrogels,\u201d \u201cbioadhesion,\u201d and \u201ccardiac tissue engineering.\u201d Studies were included based on relevance to adhesion chemistry, mechanical integration, in vivo cardiac performance, and translational outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Recent reports demonstrated improvements in ventricular remodeling, neovascularization, and scar size reduction, while early\u2010stage clinical trials report safety and potential functional benefits of AH\u2010based cardiac applications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Continued progress in material design, biocompatibility, and clinical delivery approaches is essential for translating adhesive hydrogels into routine therapies for heart management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/biot.70315","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:54:26Z","timestamp":1791284066000},"source":"Crossref","is-referenced-by-count":0,"title":["Sticking to the Heart: Adhesive Hydrogels for Cardiac Regeneration"],"prefix":"10.1002","volume":"21","author":[{"given":"Niayesh","family":"Najafi","sequence":"first","affiliation":[{"name":"Department of Translational Research, College of Osteopathic Medicine of the Pacific Western University of Health Sciences  Pomona California 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