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Thus, easy\u2010to\u2010synthesize, effective, and safe LPS\u2010inhibitors are required to develop new agents for the treatment of sepsis. On the basis of the chemical features of the toxic part of LPS, lipid A, here we present peptide\u2010based LPS\u2010neutralizers that can be readily obtained using solid\u2010phase methodologies. The presence of PEG\u2010like moieties yielded the most active compounds, thereby indicating that these functionalities may be of great value in the design of new inhibitors. In this regard, the substitution of several amino acids by PEG\u2010like chains in a previously reported cyclic anti\u2010LPS peptide (the peptide <jats:bold>RLKWc<\/jats:bold>) rendered a new derivative that retained the activity of the original peptide. We foresee that this strategy could be successfully applied to other LPS\u2010neutralizing peptides. \u00a9 2009 Wiley Periodicals, Inc. 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