{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T08:04:07Z","timestamp":1753862647994,"version":"3.41.2"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,12,4]],"date-time":"2017-12-04T00:00:00Z","timestamp":1512345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biopolymers"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Both lead intoxication in early childhood and deficient bilirubin\u2010binding capacity (BBC) of blood in jaundiced neonates indicate risk for brain damage. Zinc protoporphyrin (ZPP) is a biomarker for lead intoxication (PbI) as well as well as for iron deficiency. Under the leadership of Jack Aviv, Aviv Biomedical, Inc. developed robust hematofluorometers for point\u2010of\u2010care assays of ZPP in blood and for the high\u2010affinity BBC of blood. These assays use just drops of whole blood and are simple, fast and inexpensive. ZPP by hematofluorometry has been used world\u2010wide as a primary screen for lead intoxication since 1979. Recent clinical studies enabled by an Aviv Biomedical, Inc. bilirubin hematofluorometer have renewed interest in BBC\u2010based assessment of neurotoxicity for improved management of neonatal jaundice. This article sketches Jack Aviv's contribution to the development and application of hematofluorometry.<\/jats:p>","DOI":"10.1002\/bip.23092","type":"journal-article","created":{"date-parts":[[2017,12,5]],"date-time":"2017-12-05T10:32:25Z","timestamp":1512469945000},"source":"Crossref","is-referenced-by-count":1,"title":["Jack Aviv and brains of children"],"prefix":"10.1002","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5582-913X","authenticated-orcid":false,"given":"Angelo A.","family":"Lamola","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Neonatal and Developmental Medicine Stanford University School of Medicine Stanford California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,4]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"93","volume":"21","author":"Lamola A. 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