{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:16:48Z","timestamp":1790554608896,"version":"4.1.0"},"reference-count":86,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T00:00:00Z","timestamp":1557878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21704097"],"award-info":[{"award-number":["21704097"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21805272"],"award-info":[{"award-number":["21805272"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51873211"],"award-info":[{"award-number":["51873211"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91856113"],"award-info":[{"award-number":["91856113"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009604","name":"Changchun Science and Technology Bureau","doi-asserted-by":"publisher","award":["17DY001"],"award-info":[{"award-number":["17DY001"]}],"id":[{"id":"10.13039\/501100009604","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biopolymers"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Polypeptoids are peptidomimetic polymers invented in the early 1990s. Although polypeptoid chemistry is developing rapidly, the simple synthesis of polypeptoids and sequence\u2010controlled polypeptoids still remains a challenge. Fortunately, we have seen a drastic rising trend in the area of Ugi reaction for polypeptoid chemistry. In the following article, recent examples of the Ugi reaction for polypeptoids synthesis will be presented, as will their suitability for sequence\u2010defined peptide\u2010peptoid hybrids. The advantages and limitations of the Ugi reaction will be discussed, which is important for the simple and general synthesis of polypeptoids.<\/jats:p>","DOI":"10.1002\/bip.23288","type":"journal-article","created":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T16:17:55Z","timestamp":1557937075000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Polypeptoids synthesis based on Ugi reaction: Advances and perspectives"],"prefix":"10.1002","volume":"110","author":[{"given":"Yue","family":"Tao","sequence":"first","affiliation":[{"name":"Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied Chemistry, Chinese Academy of Sciences  Changchun China"},{"name":"College of Applied Chemistry and Engineering, University of Science and Technology of China  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Applied Chemistry and Engineering, University of Science and Technology of China  Hefei China"},{"name":"Laboratory of Polymer Composites Engineering Changchun Institute of Applied Chemistry, Chinese Academy of Sciences  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2138-2592","authenticated-orcid":false,"given":"Youhua","family":"Tao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied Chemistry, Chinese Academy of Sciences  Changchun China"},{"name":"College of Applied Chemistry and Engineering, University of Science and Technology of China  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00052a076"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmacrolett.6b00530"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/ma202319g"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.5b00201"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201500275"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.201500023"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/bip.21571"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/pola.26687"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.20.9367"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja0352101"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.progpolymsci.2018.01.002"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3sm51421h"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1039\/b817980h"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/ma1002563"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.430350105"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja066960o"},{"key":"e_1_2_6_18_1","first-page":"1440","volume":"74","author":"Fowler S. A.","year":"2009","journal-title":"J. Inorg. Chem."},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol070817y"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.333"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-08-055294-1.00256-7"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1039\/b603229j"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0015725"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi200215j"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.11.054"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar800058t"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2004.10.014"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0708254105"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/cb200300w"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-894X(01)80691-0"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/bip.21573"},{"key":"e_1_2_6_32_1","first-page":"10490","volume":"80","author":"Proulx C.","year":"2015","journal-title":"J. Inorg. Chem."},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn4015714"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja01186a524"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/macp.1977.021781114"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/macp.200400021"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/ma201015y"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja210842b"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.macromol.5b02611"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.macromol.6b00582"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/bm401542z"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmacrolett.7b00678"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1021\/ma502497x"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.macromol.8b00259"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmacrolett.8b00287"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.198208101"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/0040-4020(96)00647-3"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521-3773(20000915)39:18<3168::AID-ANIE3168>3.0.CO;2-U"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aas8707"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol702521g"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.5b00257"},{"key":"e_1_2_6_52_1","first-page":"61","volume-title":"Multi\u2010Component and Sequential Reactions in Polymer Synthesis","author":"Sehlinger A.","year":"2015"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s41061-017-0153-4"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5PY01398D"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4PY00001C"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6PY00781C"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpolymj.2015.01.032"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5PY00392J"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/pola.27610"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6GC00372A"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1021\/ma500504w"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1021\/ma201948u"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol050371q"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1039\/b901977b"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1238149"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11064"},{"key":"e_1_2_6_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201805049"},{"key":"e_1_2_6_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.530"},{"key":"e_1_2_6_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1004"},{"key":"e_1_2_6_70_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5b11631"},{"key":"e_1_2_6_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.2634"},{"key":"e_1_2_6_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201610768"},{"key":"e_1_2_6_73_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1508599112"},{"key":"e_1_2_6_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.2346"},{"key":"e_1_2_6_75_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.macromol.6b02244"},{"key":"e_1_2_6_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.2508"},{"key":"e_1_2_6_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat2742"},{"key":"e_1_2_6_78_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.7b01719"},{"key":"e_1_2_6_79_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.200900618"},{"key":"e_1_2_6_80_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol070316c"},{"key":"e_1_2_6_81_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.200700385"},{"key":"e_1_2_6_82_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0282(199612)39:6<859::AID-BIP10>3.0.CO;2-Z"},{"key":"e_1_2_6_83_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7CC06463B"},{"key":"e_1_2_6_84_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6CC09379E"},{"key":"e_1_2_6_85_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7PY01953J"},{"key":"e_1_2_6_86_1","doi-asserted-by":"publisher","DOI":"10.3762\/bjoc.10.101"},{"key":"e_1_2_6_87_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5PY00424A"}],"container-title":["Biopolymers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbip.23288","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bip.23288","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/bip.23288","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bip.23288","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T05:40:35Z","timestamp":1694238035000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bip.23288"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,15]]},"references-count":86,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1002\/bip.23288"],"URL":"https:\/\/doi.org\/10.1002\/bip.23288","archive":["Portico"],"relation":{},"ISSN":["0006-3525","1097-0282"],"issn-type":[{"value":"0006-3525","type":"print"},{"value":"1097-0282","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,15]]},"assertion":[{"value":"2018-10-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e23288"}}