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Although a change in the long\u2010range ordered structure of collagen is observed after covalent binding (Cr(III)\u2010OOC) in the presence of SO<jats:sub>4<\/jats:sub><jats:sup>2\u2212<\/jats:sup> at pH 4.5, the \u03bd<jats:sub>sym<\/jats:sub>(COO<jats:sup>\u2212<\/jats:sup>) band remains intense, suggesting a relatively lower propensity for the Cr(III) to bind covalently instead of electrostatically through Cr(H<jats:sub>2<\/jats:sub>O)<jats:sub>6<\/jats:sub><jats:sup>3+<\/jats:sup>. Replacing SO<jats:sub>4<\/jats:sub><jats:sup>2\u2212<\/jats:sup> with Cl<jats:sup>\u2212<\/jats:sup> reduces the kosmotropic effect which further favors the electrostatic binding of Cr(III) to collagen. Our findings allow a greater understanding of mechanism\u2010specific metal binding in the collagen molecule. We also report for the first time, surface\u2010enhanced Raman spectroscopy to analyze binding mechanisms in collagen, suggesting a novel way to study chemical modifications in collagen\u2010based biomaterials.<\/jats:p>","DOI":"10.1002\/bip.23406","type":"journal-article","created":{"date-parts":[[2020,11,2]],"date-time":"2020-11-02T11:59:28Z","timestamp":1604318368000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["<scp>Anion\u2010regulated<\/scp> binding selectivity of Cr(<scp>III<\/scp>) in collagen"],"prefix":"10.1002","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4196-3036","authenticated-orcid":false,"given":"Yi","family":"Zhang","sequence":"first","affiliation":[{"name":"Leather and Shoe Research Association of New Zealand  Palmerston North New Zealand"},{"name":"The MacDiarmid Institute for Advanced Materials and Nanotechnology, School of Chemical and Physical Sciences, Victoria University of Wellington  Wellington New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megha","family":"Mehta","sequence":"additional","affiliation":[{"name":"Leather and Shoe Research Association of New Zealand  Palmerston North New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bradley W.","family":"Mansel","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering National Tsing Hua University  Hsinchu City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hon Wei","family":"Ng","sequence":"additional","affiliation":[{"name":"Leather and Shoe Research Association of New Zealand  Palmerston North New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[{"name":"Leather and Shoe Research Association of New Zealand  Palmerston North New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geoff","family":"Holmes","sequence":"additional","affiliation":[{"name":"Leather and Shoe Research Association of New Zealand  Palmerston North New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3052-9947","authenticated-orcid":false,"given":"Eric C.","family":"Le Ru","sequence":"additional","affiliation":[{"name":"The MacDiarmid Institute for Advanced Materials and Nanotechnology, School of Chemical and Physical Sciences, Victoria University of Wellington  Wellington New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4371-9085","authenticated-orcid":false,"given":"Sujay","family":"Prabakar","sequence":"additional","affiliation":[{"name":"Leather and Shoe Research Association of New Zealand  Palmerston North New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,11,2]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"structure and Mechanics","author":"Fratzl P. 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