{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T18:37:58Z","timestamp":1758307078774,"version":"3.44.0"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T00:00:00Z","timestamp":1710201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100010812","name":"Fachagentur Nachwachsende Rohstoffe","doi-asserted-by":"publisher","award":["FNR 2220NR300X"],"award-info":[{"award-number":["FNR 2220NR300X"]}],"id":[{"id":"10.13039\/501100010812","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biopolymers"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Nucleophilic moieties in polysaccharides (PS) with distinct higher reactivity compared with the hydroxy group are interesting for sustainable applications in chemistry, medicine, and pharmacy. An efficient heterogeneous method for the formation of such nucleophilic PS is described. Employing alcohols as slurry medium, protonated carboxymethyl (CM) PS and hydrazine hydrate are allowed to react at elevated temperatures. The CM derivatives of starch and pullulan can be transformed almost quantitatively to the corresponding hydrazides. The reaction is less efficient for CM dextrans and CM xylans. As slurry media, 2\u2010propanol and ethanol were probed, and the results are compared with a homogeneous procedure performed in water. Overall, the heterogeneous procedure is superior compared with the homogeneous route. 2\u2010Propanol is the best slurry medium investigated yielding PS hydrazides with the highest nitrogen content.<\/jats:p>","DOI":"10.1002\/bip.23574","type":"journal-article","created":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T07:08:47Z","timestamp":1710227327000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficient heterogeneous synthesis of nucleophilic carboxymethyl hydrazides of polysaccharides"],"prefix":"10.1002","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1976-9939","authenticated-orcid":false,"given":"Hendryk","family":"W\u00fcrfel","sequence":"first","affiliation":[{"name":"Center of Excellence for Polysaccharide Research, Institute for Organic Chemistry and Macromolecular Chemistry Friedrich Schiller University Jena  Jena Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annett","family":"Pfeifer","sequence":"additional","affiliation":[{"name":"Center of Excellence for Polysaccharide Research, Institute for Organic Chemistry and Macromolecular Chemistry Friedrich Schiller University Jena  Jena Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7726-6593","authenticated-orcid":false,"given":"Thomas","family":"Heinze","sequence":"additional","affiliation":[{"name":"Center of Excellence for Polysaccharide Research, Institute for Organic Chemistry and Macromolecular Chemistry Friedrich Schiller University Jena  Jena Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,3,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781118164792"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1011929016601"},{"volume-title":"Esterification of Polysaccharides","year":"2006","author":"Heinze T.","key":"e_1_2_9_4_1"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2021.117838"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/macp.202200241"},{"key":"e_1_2_9_7_1","first-page":"56","volume":"97","author":"W\u00fcrfel H.","year":"2022","journal-title":"Lenzinger Ber."},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2022.103210"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10570-020-03659-9"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2023.121727"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2017.06.023"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.35812\/CelluloseChemTechnol.2019.53.03"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2022.120381"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-011-3477-y"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0008-6215(85)85144-2"},{"key":"e_1_2_9_16_1","unstructured":"L.Gabriel PhD Thesis Fredrich Schiller University (Jena).2021https:\/\/doi.org\/10.22032\/dbt.49169"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-9505(19990501)266:1<37::AID-APMC37>3.0.CO;2-Z"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/actp.1990.010410605"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/jp8095727"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6215(00)00120-8"}],"container-title":["Biopolymers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bip.23574","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T14:48:41Z","timestamp":1758293321000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bip.23574"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,12]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1002\/bip.23574"],"URL":"https:\/\/doi.org\/10.1002\/bip.23574","archive":["Portico"],"relation":{},"ISSN":["0006-3525","1097-0282"],"issn-type":[{"type":"print","value":"0006-3525"},{"type":"electronic","value":"1097-0282"}],"subject":[],"published":{"date-parts":[[2024,3,12]]},"assertion":[{"value":"2024-01-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e23574"}}