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This study is focused on enhancing the compressive strength of additive\u2010manufactured polylactic acid (PLA) scaffolds with a diamond structure. The response surface methodology (RSM)\u2010based experimental design was developed to study the influence of printing parameters. The fused deposition modeling (FDM) process parameters were optimized, achieving a compressive strength of 56.2\u2009MPa. Subsequently, the scaffolds were fabricated at optimized parameters and underwent ultrasonic\u2010assisted polydopamine coating. With the utilization of the RSM approach, the study examined the effects of ultrasonic vibration power, coating solution concentration, and submersion time on compressive strength. The optimal coating conditions led to a maximum compressive strength of 92.77\u2009MPa\u2014a 65.1% improvement over the uncoated scaffold. This enhancement is attributed to the scaffold's porous structure, which enables uniform coating deposition. Energy\u2010dispersive x\u2010ray spectroscopy confirmed the successful polydopamine coating, with 10.64\u2009wt% nitrogen content. These findings demonstrate the potential of ultrasonic\u2010assisted coating in improving the mechanical properties of PLA scaffolds, making them suitable for biomedical applications.<\/jats:p>","DOI":"10.1002\/bip.23629","type":"journal-article","created":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T11:35:34Z","timestamp":1727264134000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Investigating the Influence of Additive Manufacturing and Ultrasonic Coating Parameters on Biopolymeric Scaffold Performance Using Response Surface Methodology"],"prefix":"10.1002","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4901-2251","authenticated-orcid":false,"given":"Shrutika","family":"Sharma","sequence":"first","affiliation":[{"name":"Mechanical Engineering Department Thapar Institute of Engineering and Technology  Patiala Punjab 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