{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T19:05:33Z","timestamp":1776107133729,"version":"3.50.1"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T00:00:00Z","timestamp":1728432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biopolymers"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>In recent years, hydrogels have found a special place in regenerative medicine for tissue repair, rehabilitation, and drug delivery. To be used in regenerative medicine, hydrogels must have desirable physical, chemical, and biological properties. In this study, a new biomonomer based on hydroxyethyl methacrylate\u2010succinic acid\u2010polyethylene glycol 200 (HEMA\u2010Suc\u2010PEG) was synthesized and characterized. Then, using the synthesized monomers and different ratios of polyethylene glycol diacrylate (PEGDA) as a crosslinker, biocompatible hydrogels were synthesized through thermal and UV curing methods. The mechanical, physical, chemical, and biological properties of the hydrogels and the behavior of endothelial cells, an essential component of the cardiovascular system, were evaluated. The results showed that the hydrogel synthesized with 0.2\u2009g of PEGDA (UV curing) has desirable mechanical and physical properties. Biological tests showed that these hydrogels are not only nontoxic to cells but also enhance cell adhesion. Therefore, the hydrogel containing the synthesized monomer HEMA\u2010Suc\u2010PEG and 0.2\u2009g of PEGDA has the potential to be used in the cardiovascular system.<\/jats:p>","DOI":"10.1002\/bip.23631","type":"journal-article","created":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T13:35:42Z","timestamp":1728480942000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Development of <scp>HEMA<\/scp>\u2010Succinic Acid\u2010<scp>PEG<\/scp> Bio\u2010Based Monomers for High\u2010Performance Hydrogels in Regenerative Medicine"],"prefix":"10.1002","volume":"116","author":[{"given":"Hossein","family":"Rayat Pisheh","sequence":"first","affiliation":[{"name":"Biomedical Engineering Department Meybod University  Meybod Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alireza","family":"Sabzevari","sequence":"additional","affiliation":[{"name":"Biomedical Engineering Department Meybod University  Meybod Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7312-8262","authenticated-orcid":false,"given":"Mojtaba","family":"Ansari","sequence":"additional","affiliation":[{"name":"Biomedical Engineering Department Meybod University  Meybod Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kourosh","family":"Kabiri","sequence":"additional","affiliation":[{"name":"Adhesive and Resin Department Iran Polymer and Petrochemical Institute  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/25740881.2024.2358998"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13726-016-0450-8"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13726-016-0454-4"},{"key":"e_1_2_8_5_1","first-page":"453","article-title":"Conversion Lignocellulosic Bagasse Biomass Into Hydrogel","volume":"29","author":"Amiri F.","year":"2017","journal-title":"Iranian Journal of Polymer Science & Technology"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/gels8030167"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27092902"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867327666200408115817"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/gels9080617"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2024.1340893"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10047-023-01394-z"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23084118"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202001341"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7RA13510F"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202200494"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.3c00296"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00289-022-04640-1"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2020.124615"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2017.05.209"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2020.123414"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/open.202200247"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2021.125578"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23073665"},{"key":"e_1_2_8_24_1","first-page":"90","article-title":"Synthesis and Characterization of Novel pH\u2010Responsive Aminated Alginate Derivatives Hydrogels for Tissue Engineering and Drug Delivery","volume":"3","author":"Khodayar S.","year":"2023","journal-title":"Current Organic Synthesis"},{"key":"e_1_2_8_25_1","first-page":"373","article-title":"Hydrogel\u2010Based Controlled Drug Delivery for Cancer Treatment: A Review","volume":"17","author":"Sun Z.","year":"2020","journal-title":"Molecular Pharmaceutics"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym13132102"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2022.31.4.330"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.07.311"},{"key":"e_1_2_8_29_1","first-page":"1483","article-title":"Cross\u2010Linked pH\u2010Sensitive Pectin and Acrylic Acid Based Hydrogels for Controlled Delivery of Metformin","volume":"33","author":"Ali L.","year":"2020","journal-title":"Pakistan Journal of Pharmaceutical Sciences"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2019.05.027"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2020.111806"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2020.117106"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2021.131657"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-020-10556-5"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5TB02046H"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2023.129518"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.langmuir.1c01803"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevE.103.042906"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.langmuir.0c00489"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/gels8080518"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym13111772"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pbj.0000000000000187"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2023.120973"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.4c04452"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.7b01688"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2023.120702"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3TB01567J"}],"container-title":["Biopolymers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bip.23631","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T09:10:33Z","timestamp":1740561033000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bip.23631"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,9]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1002\/bip.23631"],"URL":"https:\/\/doi.org\/10.1002\/bip.23631","archive":["Portico"],"relation":{},"ISSN":["0006-3525","1097-0282"],"issn-type":[{"value":"0006-3525","type":"print"},{"value":"1097-0282","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,9]]},"assertion":[{"value":"2024-07-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e23631"}}