{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T23:51:21Z","timestamp":1792713081269,"version":"4.5.0"},"reference-count":31,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2004,2,1]],"date-time":"2004-02-01T00:00:00Z","timestamp":1075593600000},"content-version":"vor","delay-in-days":4536,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biopolymers"],"published-print":{"date-parts":[[1991,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Neurotoxic peptides from venoms of scorpions and honey bees exhibit a consensus pattern in the two disulfide bridgings related to the sequence portions Cys\u2010X\u2010Cys and Cys\u2010X\u2010X\u2010X\u2010Cys. A revised three\u2010dimensional structure of charybdotoxin, as determined by two\u2010dimensional nmr spectroscopy, confirms that the consensus cystine dislocation generates in all these toxins a common structural element, i.e., the cystine\u2010stabilized \u03b1\u2010helical (CSH) motif, which may be correlated with their common ion channel blocking activity.<\/jats:p>","DOI":"10.1002\/bip.360311009","type":"journal-article","created":{"date-parts":[[2004,12,30]],"date-time":"2004-12-30T02:31:07Z","timestamp":1104373867000},"page":"1213-1220","source":"Crossref","is-referenced-by-count":86,"title":["The cystine\u2010stabilized \u03b1\u2010helix: A common structural motif of ion\u2010channel blocking neurotoxic peptides"],"prefix":"10.1002","volume":"31","author":[{"given":"Yuji","family":"Kobayashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Takashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruhiko","family":"Tamaoki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshimasa","family":"Kyogoku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Lambert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisaya","family":"Kuroda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoyoshi","family":"Chino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takushi X.","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terutoshi","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shumpei","family":"Sakakibara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Moroder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,2]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-124570-2.50010-5"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1978.tb12106.x"},{"key":"e_1_2_1_4_2","first-page":"1022","volume":"4","author":"Miroshnikov A. I.","year":"1978","journal-title":"Bioorg. Khim."},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/bip.1981.360200209"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/332411a0"},{"key":"e_1_2_1_7_2","first-page":"543","volume":"26","author":"Takasaki C.","year":"1988","journal-title":"Toxikon"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/protein\/4.5.509"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00422a029"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(83)80159-4"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0197-0186(91)90151-3"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(90)80115-Y"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1696395"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-011-3034-9_234"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(90)92145-P"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1051\/epn\/19861701011"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(77)90207-8"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(85)90134-2"},{"key":"e_1_2_1_19_2","first-page":"s123","volume":"25","author":"Ohkubo T.","year":"1986","journal-title":"Biopolymers"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00437a050"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(83)80144-2"},{"key":"e_1_2_1_22_2","unstructured":"Bontemps F. Roumestand C. Gilquin B. Boyot P. Menez A.&Toma F.(1990) in14th International Conference of Magnetic Resonance in Biological Systems Abstract P7."},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)66914-5"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00446a019"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-198900135-00004"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/protein\/3.8.667"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2795(81)90080-5"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02907789"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.10.3329"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02009164"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2024115"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1991.tb15780.x"}],"container-title":["Biopolymers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbip.360311009","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bip.360311009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T22:00:05Z","timestamp":1698012005000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bip.360311009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,9]]},"references-count":31,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1991,9]]}},"alternative-id":["10.1002\/bip.360311009"],"URL":"https:\/\/doi.org\/10.1002\/bip.360311009","archive":["Portico"],"relation":{},"ISSN":["0006-3525","1097-0282"],"issn-type":[{"value":"0006-3525","type":"print"},{"value":"1097-0282","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,9]]}}}