{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T05:50:57Z","timestamp":1760853057071},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,2,1]],"date-time":"2004-02-01T00:00:00Z","timestamp":1075593600000},"content-version":"vor","delay-in-days":4383,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biopolymers"],"published-print":{"date-parts":[[1992,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In order to investigate the conformational variation of ascidiacyclamide, a cytotoxic cyclic peptide from marine tunicate <jats:italic>Ascidian<\/jats:italic>, single crystals were prepared from ethanol and aqueous ethanol solutions as its free form (crystal I) and H<jats:sub>2<\/jats:sub>O\/0.5 C<jats:sub>2<\/jats:sub>H<jats:sub>5<\/jats:sub>OH solvate (crystal II), respectively, and were determined by the x\u2010ray diffraction method. Crystal I showed a pseudo <jats:italic>C<\/jats:italic>2\u2010symmetric saddle\u2010shaped rectangular conformation. Similar conformations were also observed in crystal II, where there were two crystallographically independent <jats:italic>C<\/jats:italic>2\u2010symmetric molecules (named Mol\u2010A and \u2010B) per asymmetric unit. Mol\u2010A and \u2010B included H<jats:sub>2<\/jats:sub>O and H<jats:sub>2<\/jats:sub>O\/C<jats:sub>2<\/jats:sub>H<jats:sub>5<\/jats:sub>OH solvents within their ring structures, respectively. These water and ethanol molecules were located on the crystallographic dyad axes, and were stabilized by the van der Waals contacts (including hydrogen bonds) with the polar\u2010ring N atoms and nonpolar <jats:sc>D<\/jats:sc>\u2010Val side\u2010chain atoms. The conformational characteristics of ascidiacyclamide and its fluctuation\/variation were discussed based on the present and previously reported x\u2010ray results.<\/jats:p>","DOI":"10.1002\/bip.360320204","type":"journal-article","created":{"date-parts":[[2004,12,30]],"date-time":"2004-12-30T02:45:24Z","timestamp":1104374724000},"page":"131-143","source":"Crossref","is-referenced-by-count":40,"title":["Molecular conformation of ascidiacyclamide, a cytotoxic cyclic peptide from <i>Ascidian<\/i>: X\u2010ray analyses of its free form and solvate crystals"],"prefix":"10.1002","volume":"32","author":[{"given":"Toshimasa","family":"Ishida","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuko","family":"In","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsunobu","family":"Doi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatoshi","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasumasa","family":"Hamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Shiori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,2]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1039\/np9860300001"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1021\/np50055a001"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja00256a070"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo00349a002"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","unstructured":"Hamamoto Y. 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