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The nmr and CD measurements indicate that all the dehydropeptides examined adopt 3<jats:sub>10<\/jats:sub>\u2010helical conformations in solution. The tripeptides <jats:bold>1<\/jats:bold> and <jats:bold>2<\/jats:bold> exibited an intense negative CD exciton couplet, which was assigned to the right\u2010handed screw sense, while the tetrapeptide <jats:bold>3<\/jats:bold> displayed a CD couplet having opposite sign, which was assigned to the left\u2010handed helical sense. In the pentapeptide <jats:bold>4<\/jats:bold> the sense of the helix was found to vary with solvent and temperature, as demonstrated by the sign reversal of the CD spectrum. The right\u2010handed sense dominates in hexafluoro\u20102\u2010propanol, whereas a left\u2010handed helix prevails in chloroform, acetonitrile and methanol. A crucial role for this behavior is likely to be played by the two alanine residues positioned respectively at the head and tail of the sequence, which favor conformations having opposite screw senses. \u00a9 1993 John Wiley &amp; Sons, Inc.<\/jats:p>","DOI":"10.1002\/bip.360330102","type":"journal-article","created":{"date-parts":[[2004,12,30]],"date-time":"2004-12-30T03:01:11Z","timestamp":1104375671000},"page":"1-10","source":"Crossref","is-referenced-by-count":53,"title":["Solution structure of peptides containing two dehydro\u2010phenylalanine residues: A CD investigation"],"prefix":"10.1002","volume":"33","author":[{"given":"Osvaldo","family":"Pieroni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriano","family":"Fissi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Pratesi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pier Andrea","family":"Temussi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Ciardelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,2]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(81)90454-9"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(81)80521-2"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3011.1982.tb03050.x"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3011.1983.tb03094.x"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3011.1983.tb02119.x"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3011.1984.tb02712.x"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3011.1986.tb03254.x"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3011.1986.tb03255.x"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3011.1988.tb01264.x"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0108768190001367"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja00297a052"},{"key":"e_1_2_1_13_2","first-page":"S175","volume":"25","author":"Bach A.","year":"1986","journal-title":"Biopolymers"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3011.1989.tb00194.x"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0301-4622(86)85010-4"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/bip.360280306"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/bip.360300906"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/bip.360320702"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3011.1991.tb01537.x"},{"key":"e_1_2_1_20_2","doi-asserted-by":"crossref","unstructured":"Gupta A. 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